CV Lattes
Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelors and teaching degree in Biological Sciences from the Federal University of São Carlos (UFSCar), with a Masters in Medical Sciences (Biomedical Sciences) and a Ph.D. in Sciences (Medical Genetics) from the School of Medical Sciences at the University of Campinas (Unicamp). Postdoctoral training at the H. Lee Moffitt Cancer Center Research Institute (Tampa, FL, USA). Masters and doctoral research focused on the molecular mechanisms of methotrexate resistance in pediatric acute lymphoblastic leukemia, conducted at the Molecular Biology Laboratory of the Boldrini Childrens Center (Campinas, SP) and at the Brazilian Biosciences National Laboratory (LNBio/CNPEM), as part of the Nuclear Magnetic Resonance (NMR) group.Currently a researcher at the H. Lee Moffitt Cancer Center, member of Dr. Ariosto Silvas research group, working on systems biology applied to multiple myeloma and breast cancer. Also teaches Research Methodology and Scientific Writing in the graduate (lato sensu) program in Logotherapy and Existential Analysis (Franklian approach) at Universidade Ítalo-Brasileiro, Brazil. Areas of interest and expertise include therapy re-sensitization, tumor metabolism, metabolomics, and systems biology applied to cancer. (Source: Lattes Curriculum)
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Acute lymphoblastic leukemia (ALL) is the most common type of cancer in childhood. Methotrexate (MTX) is one of the main drugs used in treatment, whose mechanism of action is attributed to the inhibition of nucleotide synthesis - leading the leukemic blasts to apoptosis. However, some patients are resistant to treatment with MTX and may undergo a disease relapse; cure rates for these pati…
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