CV Lattes
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Universidade de São Paulo (USP). Escola de Educação Física e Esporte (EEFE) (Institutional affiliation from the last research proposal) Birthplace: Brazil
CNPq 1B Researcher.Graduated in Pharmacy and Biochemistry from the Federal University of Santa Maria (1986), Master in Biological Sciences (Biochemistry) from the Federal University of Rio Grande do Sul (1993) and PhD in Biological Sciences (Biochemistry and Molecular Biology) from the Federal University of Rio Grande do Sul and Laboratory of Genetics and Molecular Cardiology of the Heart Institute and Medical School of USP (1999). Since 1998 she has been a Professor of Biochemistry Applied to the Exercise at the School of Physical Education and Sport with exclusive dedication (RDIDP) at the University of São Paulo. Postdoctoral Fellow at the Stem Cells Laboratory at the Keck Graduate Institute of Applied Life Science, Claremont, California, USA (2007-2009). Associate Professor at the University of São Paulo since 2010. At that Institution, she was Chair of the Department of Biodynamic of the Human Body Movement (2014-2018), Vice-Chair of the Department (2010-2014 and 2018-2021), Chair of the Research Committee (2012-2015), Chair of the Research Ethics Committee (2014-2021). Senior Associate Researcher CNPq (10/2021-04/2022) and Fapesp (09/2022-09/2023 Fellowship, at the Health Heart Institute, Department of Internal Medicine, Morsani College of Medicine at the University of South Florida, USA. Chair of the Laboratory of Biochemistry and Molecular Biology of Exercise at EEFE-USP.Investigates the effects of physical training on non-coding RNAs in the Cardiovascular System, focusing on microRNAs and circular RNAs in the heart (physiological hypertrophy), skeletal muscle, vessels and circulating. In this context, she also investigates the effects of physical training on Myocardial Infarction, Hypertension, Diabetes and Cancer. (Source: Lattes Curriculum)
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Cancer and cardiovascular (CV) disease are a significant global public health issue and remain the main causes of morbidity and mortality worldwide. Anti-cancer therapy based on cardiotoxic agents such as the anthracyclines (DNA intercalating Topoisomerase II inhibitors) can lead to irreversible damage on cardiomyocytes ultimately causing heart failure. Strong efforts have been made to de…
Despite of the uninterrupted development of new medications for the treatment of cancer, the survival rate continues low especially in those patients in the advanced stage of the disease. Recent observations show that new therapeutics increase the susceptibility for cardiovascular diseases, which turns out to be the treatment of cancer even more complex. Cardiac dysfunction due to cardiot…
(Only some records are available in English at this moment)
Cardiovascular diseases continue to lead the global mortality ranking. Arterial hypertension is one of the main risk factors for the development of several conditions, including heart failure induced by cardiac remodeling. Associated with other mechanisms, the participation of non-coding RNA molecules (ncRNAs) act in the co- and post-transcriptional regulation of important cellular proces…
Cardiotoxicity promotes an increase in reactive oxygen species, inflammation, apoptosis, cardiac fibrosis, and these remain the main problems in the treatment of Cancer patients using doxorubicin. These associated processes induce myocardial dysfunction, decreasing the left ventricular ejection fraction, generating long-term heart failure. Some treatments have been described as attenuatin…
The metabolism of neoplastic cells is not intended to maintain homeostasis; rather, there is an imbalance that allows synthetic pathways to be enhanced and supports exaggerated and uncontrolled cell proliferation and growth. Cancer cells have the characteristic of metabolic reprogramming, which may be due to the activation of several oncogenes. This change in the metabolism of cancer cell…
Physical activity reduces the incidence of many human cancers and mitigates tumor growth and decreases metastatic tumors in different animal models of cancer. However, there is a large lack in the literature about the molecular mechanisms involved in the attenuation of tumor growth induced by aerobic physical activity. We found that mice that performed aerobic physical activity presented …
The Restenosis is a fibroproliferative response that happens on the wall of the blood vessels after an injury, usually followed by the angioplasty procedure, caused by vascular obstruction. The remodeling of the vessel caused by angioplasty is proliferation, growth and migration of smooth muscle cells of media layer for intimal, accompanied by fibrosis, leading in hyperplasia of neointima…
(Only some records are available in English at this moment)
Aerobic exercise training (AET) is known by the capacity to attenuate the deleterious effects of the myocardial infarction (MI) and heart failure as well as to increase the heart disease patient's survival. In this sense, many mechanisms are demonstrated to participate in this process, however, there is a lack in the literature on the participation of circular RNAs (circRNA) in these resp…
Pre-metastatic niche is the result of the combined systemic effects of tumor-secreted factors and tumor-shed extracellular vesicles (e.g. exosomes) that promote temporal sequence of events during the evolution of pre-metastatic niche. Aerobic exercise training reduces the incidence of several types of cancer and attenuates tumor growth in different cancer models. However, the effects of e…
Cardiomyopathy is a common human disorder that is characterized by contractile dysfunction and cardiac remodeling, generally accompanied by exercise intolerance and skeletal muscle abnormalities. Genetic mutations and altered expression of genes encoding many signaling molecules and contractile proteins are associated with cardiomyopathy; however, how cardiomyocytes sense pathophysiologic…
| 8 / 7 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 20 / 12 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 33 / 24 | All research grants and scholarships |
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