Jose Luiz Martins

Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal)
Birthplace: Brazil

Abstract
Hirschsprung's disease is characterized by the absence of ganglion cells in the distal colon, and may extend proximally at varying distances. This absence occurs when the neuroblasts stop migrating from the neural crest. The physiopathological basis for the absence of colon peristalsis in Hirschsprung's disease is not yet fully understood. This disease is an ideal model for investigation …
Study of ganglion cell and interstitial cells of Cajal in mice with intestinal aganglionosis undergoing hypoxia and reoxygenation, AP.R
Abstract
Considering that premature birth is a clinical occurrence common to patients with necrotizing enterocolitis, and that is sometimes a predictable situation, we decide to verify the hypothesis that L-arginine and/or remote ischemic preconditioning during the intra uterine phase would prevent the intestinal injury induced by neonatal hypoxia and reoxygenation. It will be utilized pregnant ra…
Intestinal lesion induced by hypoxia/reoxygenation in newborn rats. Modulation by L-arginine and remote ischemic preconditioning in uterus, AP.R
Abstract
A total of 60 newborn rats will divide into 3 groups: G1 (n=12) control group, G2 (n=24)hypoxia-reoxygenation group, and G3 (n=24) L-arginine pre-tratement by intraperitone injection and hypoxia-reoxygenation group. Pups of the groups 2 and 3 will stress twice daily with asphyxia followed by cold stress to induce hypoxic intestinal injury, whitch is relevant to human necrotizing enterocol…
Effect of L-arginine on the histopathological and biochemical alterations of the hypoxia-reoxygenation induced intestinal damage in newborn rats, AP.R

Source:Lattes Curriculum

CV Lattes

5 / 3	Completed research grants

Associated processes

Short URL

Abstract

Abstract

Abstract