Abstract
Analgesics are the main cause accidents from toxic agents exposure. Acetaminophen (APAP, 4-hidroxiacetanilida) presents analgesic and antipyretic properties, despite being safe in therapeutic doses, in cases of overdose promotes hepatic necrosis in humans and animals. The APAP is bioactivated by cytochrome P450 in a highly reactive toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI) th…