Abstract
T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of all cases of ALL in children and it is characterized by the uncontrolled expansion of T-cell lymphocytes. From the T-ALL cases described in the literature, 25% of them are involved with the IL-7R pathway. Gain-of-function mutations in IL-7R± were first described at the Boldrini Children`s Center in patients with T-ALL, wherei…