Carlos Alberto Montanari
CV Lattes
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Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Chemistry - Oswaldo Cruz (1981), MSc in Organic Chemistry (1987) and a Ph.D. in Organic Chemistry from the University of São Paulo (1991). In 1995, held a postdoctoral fellowship in Medicinal Chemistry under the supervision of Michael Tute, Pfizer / University of Kent, UK. In 2003, obtained the title of Associate Professor at the Institute of Chemistry, USP. He is currently full professor at the Institute of Chemistry of São Carlos, University of São Paulo. Has experience in the area of ​​chemistry, with an emphasis on Medicinal Chemistry, acting on the following topics: hypothesis driven molecular design, machine learning and biocalorimetry. He is currently a member of the editorial board of the Journal of Medicinal Chemistry and also of Chemical Biology & Drug Design. (Source: Lattes Curriculum)
- Molecular design and synthesis of coronavirus SARS-CoV-2 main protease (SARS CoV-2 Mpro) inhibitors, AP.R
Abstract
The current worldwide outbreak of the coronavirus with a pandemic declared by the World Health Organization (WHO) is beginning to strike in Brazilian lands. This pandemic urged us to start an emergency project in the search for new proteases inhibitors of the main coronavirus protease (SARS Cov-2 Mpro) as antiviral agents acting on the coronavirus. Several cysteine protease inhibitors (...
- Molecular design, synthesis and trypanocidal activity of cruzain reversible covalent inhibitors, AP.TEM
Abstract
Cruzain, the main cysteine protease of Trypanosoma cruzi, is an essential enzyme for the life cycle of the parasite and has been used as a viable target for searching for enzyme inhibitors as drug candidates. The peptide mimetic compound K11777 inhibits cruzain at nanomolar concentrations, and acts by an irreversible inhibition mechanism. Analogs or derivatives K11777 usually contain el...
- 7th São Carlos special medicinal chemistry meeting (SancaMedChem2019), AO.R
- Computational study of cruzain enzyme by reversible covalent inhibitors, AV.BR
Abstract
The prediction of the binding affinity has been a computational challenge, since binding process consists in multiple steps. In this propose, we will study the relationship between the relative biding free energy and the experimental data using computational approaches such as Free Energy Perturbation (FEP), molecular dynamics simulations and quantum mechanics/molecular mechanics (QM/MM...
- Molecular design of cysteine protease reversible covalent inhibitors, AV.EXT
Abstract
Cysteine proteases are important therapeutic targets in a range of human diseases, including Chagas disease (cruzain) and various cancers (cathepsins). We have an established research program for developing covalent cruzain inhibitors as novel trypanocidal agents. This program recently delivered a series of new potent chemical entities against cruzain. Two of the best compounds, Neq0593...
(Only some records are available in English at this moment)
- Molecular design and synthesis of coronavirus SARS-CoV-2 main protease (SARS Cov-2 Mpro) inhibitors, BP.PD
Abstract
The current worldwide outbreak of the coronavirus with a pandemic declared by theWorld Health Organization (WHO) is beginning to strike in Brazilian lands. Thispandemic urged us to start an emergency project in the search for new proteasesinhibitors of the main coronavirus protease (SARS Cov-2 Mpro) as antiviral agents actingon the coronavirus. Several cysteine protease inhibitors (CPs)...
- Synthesis of novel anti-Trypanosoma cruzi agents, BP.DD
Abstract
Chagas Disease is still considered a neglected disease, endemic to Latin America, and caused by the protozoan Trypanosoma cruzi. Even though it was characterized more than 100 years ago by Carlos Chagas, there are still only two methods of treatment that primarily act only in the acute phase of the disease. Benznidazole, which is the only drug used in Brazil, may have severe adverse eff...
- Synthesis of 2-aminoacetonitriles derivatives as molecular fragments of reversible covalent inhibitors of cruzain enzyme, BP.IC
Abstract
Cruzain, the main cysteine protease of Trypanosoma cruzi, is an essential enzyme for the life cycle of the parasite and has been used in the NEQUIMED/IQSC/USP group for the identification of new trypanocidal agents. The substances synthesized in in the group in the era of the thematic project FAPESP #2013/18009-4, are active against cruzain in concentrations of low-nanomolar down to sub...
- On the synthesis of new trypanocidal agents for the treatment of Chagas Disease, BP.PD
Abstract
Cruzain, the main cysteine protease of Trypanosoma cruzi, is an essential enzyme for the life cycle of the parasite and has been used as a viable target for searching for enzyme inhibitors as drug candidates. The peptide mimetic compound K11777 inhibits cruzain at nanomolar concentrations, and acts by an irreversible inhibition mechanism. Analogs or derivatives K11777 usually contain el...
- Molecular design, synthesis, and trypanocidal activity of reversible covalent inhibitors of cruzain enzyme, BP.PD
Abstract
Cysteine proteases provide targets useful for the treatment of various diseases that affect humans. In disorders caused by parasitic infection, cruzain is a target for enzymatic inhibition. The reactive and active catalytic cysteine site (Cys25) provides specificity for many inhibitors, but obtaining selectivity within families of cysteine proteases and their isoenzymes can be problemat...
(Only some records are available in English at this moment)
- Molecular design and synthesis of new cruzain inhibitors with trypanocidal activity, BE.EP.DD
Abstract
Cruzain is an established target for the identification of novel trypanocidal agents, but how good are in vitro/in vivo correlations for active compounds? This project aims at the development of computational models for the prediction of the properties of cruzain inhibitors that are Trypanosoma cruzi killers. We will systematically analyze structure-activity relationships (SARs), visual...
- Synthesis of cruzain inhibitors for dipeptidyl nitriles warhead exchange, BE.EP.DR
Abstract
The proponent is a FAPESP fellow (process 2013/01128-0), which is linked to the thematic project 2013/18009-4 under my supervision and presents this project of work to request a BEPE type scholarship to the University of Washington in Seattle, USA, under the supervision of Prof. Michael Gelb. Our best cruzain inhibitors (sub-micromolar) kill T. cruzi in varying concentrations and severa...
- Hit-to-lead optimization of Trypanosoma cruzi dihydroorotate dehydrogenase inhibitors, BE.EP.PD
Abstract
In the last few years, our research group has been focusing on the design of inhibitors targeting the enzyme dihydroorotate dehydrogenase from Trypanosoma Cruzi (TcDHODH). In order to accomplish this, we have applied computational and biochemical methods to investigate structural and catalytic mechanism properties which might be useful to the identification of small molecules able to mo...
| 2 / 2 | Ongoing research grants |
| 19 / 16 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 21 / 18 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 47 / 41 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 51 |
| Citations | 287 |
| Cit./Article | 5.6 |
| Data from Web of Science | |
SANTA CRUZ, ELISA C.; CARECHO, ADRIEL R.; SAIDEL, MARTA E.; MONTANARI, CARLOS ALBERTO; LEITAO, ANDREI. In silico selection and cell-based characterization of selective and bioactive compounds for androgen-dependent prostate cancer cell. Bioorganic & Medicinal Chemistry Letters, v. 27, n. 3, p. 546-550, FEB 1 2017. Web of Science Citations: 3. (13/18009-4, 11/07025-3)
BURTOLOSO, ANTONIO C. B.; DE ALBUQUERQUE, SERGIO; FURBER, MARK; GOMES, JULIANA C.; GONCALEZ, CRISTIANA; KENNY, PETER W.; LEITAO, ANDREI; MONTANARI, CARLOS A.; QUILLES JUNIOR, JOSE CARLOS; RIBEIRO, JEAN F. R.; et al. Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors. PLoS Neglected Tropical Diseases, v. 11, n. 2, FEB 2017. Web of Science Citations: 5. (13/18009-4)
POSSATO, BRUNA; CARNEIRO, ZUMIRA APARECIDA; DE ALBUQUERQUE, SERGIO; NIKOLAOU, SOFIA. New uses for old complexes: The very first report on the trypanocidal activity of symmetric trinuclear ruthenium complexes. Journal of Inorganic Biochemistry, v. 176, p. 156-158, NOV 2017. Web of Science Citations: 1. (13/18009-4, 15/20302-7)
SILVA, DANIEL G.; RIBEIRO, JEAN F. R.; DE VITA, DANIELA; CIANNI, LORENZO; FRANCO, CAIO HADDAD; FREITAS-JUNIOR, LUCIO H.; MORAES, CAROLINA BORSOI; ROCHA, JOSMAR R.; BURTOLOSO, ANTONIO C. B.; KENNY, PETER W.; et al. A comparative study of warheads for design of cysteine protease inhibitors. Bioorganic & Medicinal Chemistry Letters, v. 27, n. 22, p. 5031-5035, NOV 15 2017. Web of Science Citations: 6. (13/18009-4, 13/01128-0, 15/14304-7, 16/10362-5)
BERNARDIM, BARBARA; COUCH, ERICA D.; HARDMAN-BALDWIN, ANDREA M.; BURTOLOSO, ANTONIO C. B.; MATTSON, ANITA E.. Divergent Roles of Urea and Phosphoric Acid Derived Catalysts in Reactions of Diazo Compounds. SYNTHESIS-STUTTGART, v. 48, n. 5, p. 677-686, MAR 2016. Web of Science Citations: 11. (13/18009-4, 13/25504-1, 13/50312-9, 12/22274-2)
CIANNI, LORENZO; FELDMANN, CHRISTIAN WOLFGANG; GILBERG, ERIK; GUETSCHOW, MICHAEL; JULIANO, LUIZ; LEITAO, ANDREI; BAJORATH, JUERGEN; MONTANARI, CARLOS A.. Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?. Journal of Medicinal Chemistry, v. 62, n. 23, p. 10497-10525, DEC 12 2019. Web of Science Citations: 1. (13/18009-4, 16/07946-5)
SANTIAGO, JOAO VICTOR; BURTOLOSO, ANTONIO C. B.. Rapid Synthesis of Bicyclic N-Heterocyclic Cores from N-Terminal ,-Unsaturated Diazoketones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2018, n. 22, p. 2822-2830, JUN 15 2018. Web of Science Citations: 2. (13/18009-4)
CIANNI, LORENZO; SARTORI, GERALDO; ROSINI, FABIANA; DE VITA, DANIELA; PIRES, GABRIEL; LOPES, BIANCA REBELO; LEITAO, ANDREI; BURTOLOSO, ANTONIO C. B.; MONTANARI, CARLOS A.. Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors. BIOORGANIC CHEMISTRY, v. 79, p. 285-292, SEP 2018. Web of Science Citations: 4. (13/18009-4)
SANTIAGO, JOAO VICTOR; BURTOLOSO, ANTONIO C. B.. Synthesis of Fused Bicyclic [1,2,3]-Triazoles from gamma-Amino Diazoketones. ACS OMEGA, v. 4, n. 1, p. 159-168, JAN 2019. Web of Science Citations: 0. (13/18009-4, 13/25504-1, 17/23329-9)
GALLO, RAFAEL DOUGLAS C.; BURTOLOSO, ANTONIO C. B.. Silica-supported HClO4 promotes catalytic solvent- and metal-free O-H insertion reactions with diazo compounds. GREEN CHEMISTRY, v. 20, n. 19, p. 4547-4556, SEP 7 2018. Web of Science Citations: 3. (13/18009-4, 17/23329-9)
MOMO, PATRICIA B.; LEVEILLE, ALEXANDRIA N.; FARRAR, ELLIOT H. E.; GRAYSON, MATTHEW N.; MATTSON, ANITA E.; BURTOLOSO, ANTONIO C. B.. Enantioselective S-H Insertion Reactions of alpha-Carbonyl Sulfoxonium Ylides. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, MAY 2020. Web of Science Citations: 0. (13/18009-4, 18/19105-0, 17/23329-9)
SARTORI, GERALDO RODRIGUES; LEITAO, ANDREI; MONTANARI, CARLOS A.; LAUGHTON, CHARLES A.. Ligand-induced conformational selection predicts the selectivity of cysteine protease inhibitors. PLoS One, v. 14, n. 12, DEC 19 2019. Web of Science Citations: 1. (13/18009-4)
TALERO, ALEXANDER GARAY; MARTINS, BRUNA SIMOES; BURTOLOSO, ANTONIO C. B.. Coupling of Sulfoxonium Ylides with Arynes: A Direct Synthesis of Pro-Chiral Aryl Ketosulfoxonium Ylides and Its Application in the Preparation of alpha-Aryl Ketones. ORGANIC LETTERS, v. 20, n. 22, p. 7206-7211, NOV 16 2018. Web of Science Citations: 9. (13/18009-4, 17/02092-0, 17/23329-9)
WIGGERS‚ HJ; CHELESKI‚ J.; ZOTTIS‚ A.; OLIVA‚ G.; ANDRICOPULO‚ A.D.; MONTANARI‚ C.A.. Effects of organic solvents on the enzyme activity of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase in calorimetric assays. Analytical Biochemistry, v. 370, n. 1, p. 107-114, 2007. (05/01282-3)
AVELAR, LEANDRO A. A.; CAMILO, CRISTIAN D.; DE ALBUQUERQUE, SERGIO; FERNANDES, WILLIAM B.; GONCALEZ, CRISTIANA; KENNY, PETER W.; LEITAO, ANDREI; MCKERROW, JAMES H.; MONTANARI, CARLOS A.; MENACA OROZCO, ERIKA V.; et al. Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors. PLoS Neglected Tropical Diseases, v. 9, n. 7, JUL 2015. Web of Science Citations: 12. (13/18009-4)
LEITAO, RENAN C. F.; TRUJILLO, LOREN N.; LEITAO, ANDREI; ALBUQUERQUE, RODRIGO Q.. On the use of porous nanomaterials to photoinactivate E. coli with natural sunlight irradiation. Solar Energy, v. 122, p. 1117-1122, DEC 2015. Web of Science Citations: 1. (13/18009-4, 12/02955-5)
KENNY, PETER W.; MONTANARI, CARLOS A.; PROKOPCZYK, IGOR M.; RIBEIRO, JEAN F. R.; SARTORI, GERALDO RODRIGUES. Hydrogen Bond Basicity Prediction for Medicinal Chemistry Design. Journal of Medicinal Chemistry, v. 59, n. 9, SI, p. 4278-4288, MAY 12 2016. Web of Science Citations: 19. (13/18009-4)
KAWAMURA, MEIRE Y.; TALERO, ALEXANDER G.; SANTIAGO, JOAO V.; GARAMBEL-VILCA, EDSON; ROSSET, ISAC G.; BURTOLOSO, ANTONIO C. B.. Six-Step Syntheses of (-)-1-Deoxyaltronojirimycin and (+)-1-Deoxymannonojirimycin from N-Z-O-TBDPS-L-serinal. Journal of Organic Chemistry, v. 81, n. 21, p. 10569-10575, NOV 4 2016. Web of Science Citations: 5. (13/18009-4, 13/25504-1, 13/26399-7)
DIAS, RAFAEL M. P.; MOMO, PATRICIA B.; BURTOLOSO, ANTONIO C. B.. One-step syntheses of substituted 2-pyrrolidinones and 3-pyrrolidinones from alpha,beta-unsaturated diazoketones and amines. Application in the synthesis of barmumycin. Tetrahedron, v. 73, n. 26, p. 3720-3729, JUN 29 2017. Web of Science Citations: 7. (13/18009-4, 13/25504-1, 15/22003-7)
SILVA, DANIEL G.; GILLESPIE, J. ROBERT; RANADE, RANAE M.; HERBST, ZACKARY M.; NGUYEN, UYEN T. T.; BUCKNER, FREDERICK S.; MONTANARI, CARLOS A.; GELB, MICHAEL H.. New Class of Antitrypanosomal Agents Based on Imidazopyridines. ACS Medicinal Chemistry Letters, v. 8, n. 7, p. 766-770, JUL 2017. Web of Science Citations: 6. (13/01128-0, 13/18009-4, 16/10362-5)
GALLO, RAFAEL D. C.; AHMAD, ANEES; METZKER, GUSTAVO; BURTOLOSO, ANTONIO C. B.. alpha,alpha-Alkylation-Halogenation and Dihalogenation of Sulfoxonium Ylides. A Direct Preparation of Geminal Difunctionalized Ketones. CHEMISTRY-A EUROPEAN JOURNAL, v. 23, n. 67, p. 16980-16984, DEC 1 2017. Web of Science Citations: 13. (13/18009-4)
BORGES, NADIA MELO; KENNY, PETER W.; MONTANARI, CARLOS A.; PROKOPCZYK, IGOR M.; RIBEIRO, JEAN F. R.; ROCHA, JOSMAR R.; SARTORI, GERALDO RODRIGUES. The influence of hydrogen bonding on partition coefficients. Journal of Computer-Aided Molecular Design, v. 31, n. 2, p. 163-181, FEB 2017. Web of Science Citations: 8. (13/18009-4)
TALERO, ALEXANDER G.; BURTOLOSO, ANTONIO C. B.. Sharpless Asymmetric Dihydroxylation on ,-Unsaturated Diazoketones: A New Entry for the Synthesis of Disubstituted Furanones. Synlett, v. 28, n. 14, p. 1748-1752, SEP 2017. Web of Science Citations: 5. (13/18009-4, 13/25504-1)
DA SILVA, ALLAN RIBEIRO; DOS SANTOS, DEBORAH ARAUJO; PAIXAO, MARCIO WEBER; CORREA, ARLENE GONCALVES. Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines. Molecules, v. 24, n. 3, FEB 1 2019. Web of Science Citations: 3. (14/50249-8, 18/09961-7, 17/23867-0)
KENNY, PETER W.; LEITAO, ANDREI; MONTANARI, CARLOS A.. Ligand efficiency metrics considered harmful. Journal of Computer-Aided Molecular Design, v. 28, n. 7, p. 699-710, JUL 2014. Web of Science Citations: 28. (11/20572-3, 11/01893-3)
PROKOPCZYK, IGOR M.; RIBEIRO, JEAN F. R.; SARTORI, GERALDO R.; SESTI-COSTA, RENATA; SILVA, JOAO S.; FREITAS, RENATO F.; LEITAO, ANDREI; MONTANARI, CARLOS A.. Integration of methods in cheminformatics and biocalorimetry for the design of trypanosomatid enzyme inhibitors. Future Medicinal Chemistry, v. 6, n. 1, p. 17-33, JAN 2014. Web of Science Citations: 6. (11/01893-3)
QUILLES JUNIOR, JOSE C.; ROCHO CARLOS, FERNANDA DOS REIS; MONTANARI, A.; LEITAO, ANDREI; MIGNONE, VIVIANE W.; ARRUDA, MARIA AUGUSTA; TURYANSKA, LYUDMILA; BRADSHAW, TRACEY D.. Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. RSC ADVANCES, v. 9, n. 63, p. 36699-36706, NOV 11 2019. Web of Science Citations: 0. (13/18009-4, 14/07292-0)
DA COSTA, CLAUBER H. S.; BONATTO, VINICIUS; DOS SANTOS, ALBERTO M.; LAMEIRA, JERONIMO; LEITAO, ANDREI; MONTANARI, CARLOS A.. Evaluating QM/MM Free Energy Surfaces for Ranking Cysteine Protease Covalent Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 60, n. 2, p. 880-889, FEB 2020. Web of Science Citations: 1. (13/18009-4, 18/21749-3)
SILVA, JOSE ROGERIO A.; CIANNI, LORENZO; ARAUJO, DEBORAH; JATAI BATISTA, PEDRO HENRIQUE; DE VITA, DANIELA; ROSINI, FABIANA; LEITAO, ANDREI; LAMEIRA, JERONIMO; MONTANARI, CARLOS A.. Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 60, n. 3, p. 1666-1677, MAR 23 2020. Web of Science Citations: 0. (13/18009-4, 18/21749-3)
GOMES, JULIANA C.; CIANNI, LORENZO; RIBEIRO, JEAN; ROCHO, FERNANDA DOS REIS; MARTINS SILVA, SAMELYN DA COSTA; JATAI BATISTA, PEDRO HENRIQUE; MORAES, CAROLINA BORSOI; FRANCO, CAIO HADDAD; FREITAS-JUNIOR, LUCIO H. G.; KENNY, PETER W.; et al. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorganic & Medicinal Chemistry, v. 27, n. 22, NOV 15 2019. Web of Science Citations: 0. (13/18009-4, 16/07946-5)
CIANNI, LORENZO; FELDMANN, CHRISTIAN WOLFGANG; GILBERG, ERIK; GUETSCHOW, MICHAEL; JULIANO, LUIZ; LEITAO, ANDREI; BAJORATH, JUERGEN; MONTANARI, CARLOS A.. Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?. Journal of Medicinal Chemistry, v. 62, n. 23, p. 10497-10525, DEC 12 2019. Web of Science Citations: 1. (13/18009-4, 16/07946-5)
DOS SANTOS, DEBORAH A.; DA SILVA, ALLAN R.; ELLENA, JAVIER; DA SILVA, CECILIA C. P.; PAIXAO, MARCIO W.; CORREA, ARLENE G.. Green One-Pot Asymmetric Synthesis of Peptidomimetics via Sequential Organocatalyzed Aziridination and Passerini Multicomponent Reaction. SYNTHESIS-STUTTGART, v. 52, n. 7, p. 1076-1086, APR 1 2020. Web of Science Citations: 0. (14/50249-8, 13/07600-3, 18/09961-7, 17/23867-0)
CIANNI, LORENZO; LEMKE, CARINA; GILBERG, ERIK; FELDMANN, CHRISTIAN; ROSINI, FABIANA; ROCHO, FERNANDA DOS REIS; RIBEIRO, JEAN F. R.; TEZUKA, DAIANE Y.; LOPES, CARLA D.; DE ALBUQUERQUE, SERGIO; et al. Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents. PLoS Neglected Tropical Diseases, v. 14, n. 3, MAR 2020. Web of Science Citations: 0. (13/18009-4, 16/07946-5, 17/17386-0)
TEZUKA, DAIANE YUKIE; DE ALBUQUERQUE, SERGIO; MONTANARI, CARLOS ALBERTO; LEITAO, ANDREI. Discovery of 2-aminopyridine Derivatives with Antichagasic and Antileishmanial Activity Using Phenotypic Assays. LETTERS IN DRUG DESIGN & DISCOVERY, v. 17, n. 7, p. 867-872, 2020. Web of Science Citations: 0. (13/18009-4, 18/15904-6)
SANTIAGO, JOAO VICTOR; BURTOLOSO, ANTONIO C. B.. Rapid Synthesis of Bicyclic N-Heterocyclic Cores from N-Terminal ,-Unsaturated Diazoketones. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2018, n. 22, p. 2822-2830, JUN 15 2018. Web of Science Citations: 2. (13/18009-4)
CIANNI, LORENZO; SARTORI, GERALDO; ROSINI, FABIANA; DE VITA, DANIELA; PIRES, GABRIEL; LOPES, BIANCA REBELO; LEITAO, ANDREI; BURTOLOSO, ANTONIO C. B.; MONTANARI, CARLOS A.. Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors. BIOORGANIC CHEMISTRY, v. 79, p. 285-292, SEP 2018. Web of Science Citations: 4. (13/18009-4)
GALLO, RAFAEL DOUGLAS C.; BURTOLOSO, ANTONIO C. B.. Silica-supported HClO4 promotes catalytic solvent- and metal-free O-H insertion reactions with diazo compounds. GREEN CHEMISTRY, v. 20, n. 19, p. 4547-4556, SEP 7 2018. Web of Science Citations: 3. (13/18009-4, 17/23329-9)
GALLO, RAFAEL D. C.; CAMPOVILLA, JR., ORLANDO C.; AHMAD, ANEES; BURTOLOSO, ANTONIO C. B.. Synthesis of Oxazinanones: Intramolecular Cyclization of Amino Acid-Derived Diazoketones via Silica-Supported HClO4 Catalysis. FRONTIERS IN CHEMISTRY, v. 7, FEB 8 2019. Web of Science Citations: 1. (13/18009-4, 15/20084-0, 17/23329-9)
BERNARDIM, BARBARA; COUCH, ERICA D.; HARDMAN-BALDWIN, ANDREA M.; BURTOLOSO, ANTONIO C. B.; MATTSON, ANITA E.. Divergent Roles of Urea and Phosphoric Acid Derived Catalysts in Reactions of Diazo Compounds. SYNTHESIS-STUTTGART, v. 48, n. 5, p. 677-686, MAR 2016. Web of Science Citations: 11. (13/18009-4, 13/25504-1, 13/50312-9, 12/22274-2)
SANTA CRUZ, ELISA C.; CARECHO, ADRIEL R.; SAIDEL, MARTA E.; MONTANARI, CARLOS ALBERTO; LEITAO, ANDREI. In silico selection and cell-based characterization of selective and bioactive compounds for androgen-dependent prostate cancer cell. Bioorganic & Medicinal Chemistry Letters, v. 27, n. 3, p. 546-550, FEB 1 2017. Web of Science Citations: 3. (13/18009-4, 11/07025-3)
DA SILVA, ALLAN RIBEIRO; DOS SANTOS, DEBORAH ARAUJO; PAIXAO, MARCIO WEBER; CORREA, ARLENE GONCALVES. Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines. Molecules, v. 24, n. 3, FEB 1 2019. Web of Science Citations: 3. (14/50249-8, 18/09961-7, 17/23867-0)
QUILLES JR, JOSE C.; TEZUKA, DAIANE Y.; LOPES, CARLA D.; RIBEIRO, FERNANDA L.; LAUGHTON, CHARLES A.; DE ALBUQUERQUE, SERGIO; MONTANARI, CARLOS A.; LEITAO, ANDREI. Dipeptidyl nitrile derivatives have cytostatic effects against Leishmania spp. promastigotes. Experimental Parasitology, v. 200, p. 84-91, MAY 2019. Web of Science Citations: 2. (13/18009-4, 14/07292-0)
QUILLES JR, JOSE C.; BERNARDI, MURILLO D. L.; BATISTA, PEDRO H. J.; SILVA, SAMELYN C. M.; ROCHA, CAMILA M. R.; MONTANARI, CARLOS A.; LEITAO, ANDREI. Biological Activity and Physicochemical Properties of Dipeptidyl Nitrile Derivatives Against Pancreatic Ductal Adenocarcinoma Cells. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 19, n. 1, p. 112-120, 2019. Web of Science Citations: 2. (13/18009-4, 14/07292-0)
BATISTA, FERNANDA A. H.; RAMOS, JR., SERGIO L.; TASSONE, GIUSY; LEITAO, ANDREI; MONTANARI, CARLOS A.; BOTTA, MAURIZIO; MORI, MATTIA; BORGES, JULIO C.. Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 35, n. 1, p. 639-649, JAN 1 2020. Web of Science Citations: 0. (13/10712-8, 17/26131-5, 14/07206-6, 11/23110-0, 13/18009-4, 12/50161-8, 17/07335-9)
MOMO, PATRICIA B.; LEVEILLE, ALEXANDRIA N.; FARRAR, ELLIOT H. E.; GRAYSON, MATTHEW N.; MATTSON, ANITA E.; BURTOLOSO, ANTONIO C. B.. Enantioselective S-H Insertion Reactions of alpha-Carbonyl Sulfoxonium Ylides. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, MAY 2020. Web of Science Citations: 0. (13/18009-4, 18/19105-0, 17/23329-9)
SARTORI, GERALDO RODRIGUES; LEITAO, ANDREI; MONTANARI, CARLOS A.; LAUGHTON, CHARLES A.. Ligand-induced conformational selection predicts the selectivity of cysteine protease inhibitors. PLoS One, v. 14, n. 12, DEC 19 2019. Web of Science Citations: 1. (13/18009-4)
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