Andréa Coelho de Barros

• Abstract

  There are several nuclear transport pathways that transport of macromolecules into or out of the nucleus through recognition of specific signal sequences, the classic nuclear protein import pathway is the best characterized of these transport cycles. In this process, the structural study of Importin-± (IMP±) is the key for your understanding. This protein was recently crystallized and its…

  Structural characterization of transport mechanism to the cell nucleus of glycogen-related proteins metabolism in Neurospora crassa, BP.PD

• Abstract

  The stability and integrity of the genetic material are essential for the maintenance and continuation of life. The human genome, comprising three billion base pairs coding for 30.000 - 40.000 genes, is constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of environmental mutagens that impact its integrity. Thus it is obvious that the stability of the g…

  Structural studies with mammalian importin-alpha and nuclear localization sequences (NLS) from proteins involved in DNA repair, BP.DR
• Structural studies with a mammalian importin-a and nuclear localization sequence (NLS) peptides., BP.MS

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