CV Lattes
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Universidade Universus Veritas Guarulhos (Univeritas UNG) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Degree in Biological Sciences from the Catholic University of Paraná (2007) and specialist in microbiology from Catholic University of Parana. PhD in Pharmacology by the Odontology program in the Piracicaba Dentistry School Piracicaba / UNICAMP (CAPES 7) in 2014. Postdoctoral fellow at the Federal University of Paraná (2014-2015) in the Pharmacology Department (Laboratory of Pain Pharmacology). Post-Doctoral Junior CNPq (2015-2017) in Pharmacology at the Faculty of Dentistry of Piracicaba (UNICAMP). Postdoctoral fellow (2017-2018) at East Carolina University, Department Foundation Sciences, School of Dental Medicine. Professor and vice coordinator at the Stricto Sensu Postgraduate Program at Guarulhos University (UNG).Coordinator of the Ethics Committee for the Use of Animals at Guarulhos University (CEUA-UNG). Ministrate the disciplines of Biochemistry and Pharmacology for undergraduate courses. scientific collaboration with several research groups from different national institutions: Pain Studies Laboratory (UFPR), Biomembrane Laboratory (IB/UNICAMP), Pharmacology Laboratory (FOP/UNICAMP), Hospital das Clinicas de Curitiba (UFPR) and FIOCRUZThe main research field: drug delivery systems, local anesthetics, cytotoxicity, inflammatory response and analgesia. The research involves the evaluation of local anesthetics associated to drug delivery systems in in vitro and in vivo models of inflammation, inflammatory pain and neuropathic pain. Contributes as reviewer in journals indexed in international databases and member of the Review Board in Frontiers in Oral Health. (Source: Lattes Curriculum)
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Migraine is a complex and quite frequent neurological disorder, without a fully elucidated pathophysiological mechanism. This condition involves trigeminovascular system activation, neuropeptide release, neuroinflammation and vasodilation. Drug repositioning is an efficient strategy in order to expand the pharmacological arsenal. Thus, maraviroc, a CCR5 receptor antagonist, emerges as a c…
Local anesthetics (LA) are widely used for pain control in many clinical procedures and other therapeutic applications. These molecules can interact with several cellular structures in different signaling pathways and may modulate the inflammatory response. However, the use of LAs is restricted due to a rapid dispersion from injected site. The complexation of LA in cyclodextrin have shown…
Activation of the neuroimmune system can trigger a neuroinflammatory process, resulting in central and peripheral sensitization. Inflammatory responses in the nervous system can be triggered by neuronal activity, involving the release of neuropeptides such as CGRP. Neuroimmunological changes lead to the activation of microglia cells, inducing the release of cytokines and chemokines. ¿-che…
The development of drugs able to produce long-lasting analgesia, with lower systemic toxicity and few adverse effects would be of great benefit for acute and chronic pain control. Bupivacaine is a long-acting local anesthetic with strong action, however, it has lower solubility and higher toxicity. The complexation of LA in cyclodextrin has shown improvements in aqueous solubility, reduce…
Local anesthetics (LAs) are widely used for pain control in many clinical procedures or in another kind, and also have other therapeutic applications. Bupivacaine is a long-lasting LA with increased potency, however, it has lower solubility and higher toxicity. The complexation of LA on cyclodextrins has demonstrated reduced systemic toxicity, improvements on aqueous solubility and other …
The most effective control of pain has motivated the search for new local anesthetic formulations. The association with carriers has been proposed in order to prolong the anesthetic effect and reducing its toxicity. New anesthetic formulations produced a low systemic toxicity and longer duration of anesthesia. Adverse effects were also observed as the appearance of inflammatory painless w…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 1 / 1 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 4 / 4 | Completed scholarships in Brazil |
| 7 / 7 | All research grants and scholarships |
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