Natalia Juliana Nardelli Gonçalves

• Abstract

  The Duchenne muscular dystrophy is a genetic disorder that generates progressive degeneration of skeletal muscles. The gene encoding dystrophin protein is formed by 79 exons, and its size makes it very susceptible to mutations. The Golden Retriever Muscular Dystrophy (GRMD) is genetically homologous to muscular dystrophy Duchenne (DMD) which affects humans, and this animal model is what m…

  Molecular characterization of Duchenne Muscular Dystrophy in a canine Golden Retriever model (GRMD), BP.IC

• Abstract

  The induced reprogramming strategies are being employed in order to induce somatic cells to a pluripotent state, similar to the embryonic. The nuclear reprogramming process is highly desirable and has significant contributions from the study of basic and applied science, for example, increasing the efficiency of animal production of biotechnical and medicine, with the possibility of autol…

  Gene edition by CRISPR-Cas9 in the correction of Duchenne muscular dystrophy in a canine model (GRMD) from induced pluripotent stem cells, BP.PD

• Abstract

  Recent trials with animal models have shown the great importance of embryonic pluripotent stem cells for the treatment of various diseases, many of them extremely complex. Regenerative medicine supported by the development of biotechnology emerges with a promising future, one of the most desired therapeutic options. In this context, obtaining stem cell lineages from dog embryos is still a…

  Generation of canine pluripotent stem cell through in vivo and in vitro mechanisms, BP.DR

(Only some records are available in English at this moment)

• Abstract

  Direct reprogramming generates induced pluripotent stem cells (iPSCs) with similar molecular proles and developmental potential of embryonic stem cells (ESCs); however, several studies have suggested that subtle differences in gene expression or chromatin modications yield iPS cell lines with reduced pluripotency when compared to ESCs. To harness the full potential of iPSC technology, it …

  The establishment and culture of iPS from canine fibroblasts, BE.EP.DR