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The establishment and culture of iPS from canine fibroblasts

Grant number: 12/09631-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 15, 2012
Effective date (End): November 14, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Carlos Eduardo Ambrósio
Grantee:Natalia Juliana Nardelli Gonçalves
Supervisor abroad: Jorge A. Piedrahita
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Local de pesquisa : North Carolina State University (NC State), United States  
Associated to the scholarship:11/22915-5 - Generation of canine pluripotent stem cell through in vivo and in vitro mechanisms, BP.DR


Direct reprogramming generates induced pluripotent stem cells (iPSCs) with similar molecular proles and developmental potential of embryonic stem cells (ESCs); however, several studies have suggested that subtle differences in gene expression or chromatin modications yield iPS cell lines with reduced pluripotency when compared to ESCs. To harness the full potential of iPSC technology, it is important to understand the mechanisms underlying these questions. The canine model is especially important to address the potential use of these cells in regenerative medicine once it provides trustful information derived from several natural disease models. Therefore, the aim of this study is to dissect the cellular mechanisms involved in pluripotency in dogs for the establishment of iPS cells, in addition to the development of genome editing techniques, that can be used for cell therapy and other purposes (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre a bolsa:
Brazilian and U.S. researchers team up to develop a safe line of stem cells to treat marrow lesions 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GONCALVES, N. J. N.; BRESSAN, F. F.; ROBALLO, K. C. S.; MEIRELLES, F. V.; XAVIER, P. L. P.; FUKUMASU, H.; WILLIAMS, C.; BREEN, M.; KOH, S.; SPER, R.; PIEDRAHITA, J.; AMBROSIO, C. E. Generation of LIF-independent induced pluripotent stem cells from canine fetal fibroblasts. Theriogenology, v. 92, p. 75-82, APR 1 2017. Web of Science Citations: 10.

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