Abstract
Tumor growth and progression depend on angiogenesis, the growth of new blood vessels from a pre-existing vascular endothelium. The Vascular Endothelium Growth Factor (VEGF) is a potent endothelial cell mitogen. Increased VEGF expression is associated with tumor growth and metastasis. Nevertheless, 3' alternative splice site selection in exon 8 of VEGF gene results in a sister family of is…