CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine at the Faculdade de Medicina da Universidade de São Paulo (1983), Master degree in Allergology and Clinical Imunology at the Universidade de São Paulo (1993) and PhD in Pathology at the Universidade de São Paulo (1996). Presently, professor at the Faculdade de Medicina da Universidade de São Paulo, and head of the Laboratório de Micologia Médica (LIM-53) from the Divisão de Clínica Dermatologica, Hospital das Clínicas/Instituto de Medicina Tropical, FMUSP, and Medical-researcher of the Laboratório de Investigação em Dermatologia e Imunodeficiências (LIM56, Divisão de Clínica Dermatológica HC-FMUSP). Main areas of expertise are the study of the host-parasite interaction, with emphasis in leprosy and paracoccidioidomycosis, and new tools in mycological diagnosis; started a new area of research in immunosenescence. Member of the Research Committee of the FMUSP. (Source: Lattes Curriculum)
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The HIV epidemic remains a global challenge, with more than 40 million people living with the virus. The advent of antiretroviral therapy (ART) has transformed HIV infection into a chronic condition, enabling longer survival. However, people living with HIV (PLWH) experience accelerated immune aging, characterized by cellular dysfunction, chronic inflammation, and a higher incidence of ag…
The development of this project came naturally after completing Thematic Project 2016/08730-6 entitled: Fungal pathogenicity: Effect of smoking, immune response and vaccine modulation in paracoccidioidomycosis and histoplasmosis. Important aspects related to pathophysiology and control of systemic fungal diseases were answered, however new questions directed to diagnosis, innate and adapt…
The skin is the largest organ in the body and is the site for a diverse set of diseases. Yet, given the complexity of the cutaneous tissue, there is a limited availability of data in the literature on skin proteomics. Here, we proposed an adapted and optimized protocol for the extraction of proteins from human skin, using a combination of chemical and mechanical lysis approaches. For this…
The fact that COVID-19 pandemia has led to an unprecedented, worldwide effort to develop a vaccine able to confer protection to a large and heterogeneous population, gave rise to the reemergence of the issue of vaccination of elderly and those bearing chronic diseases. While these populations show enhanced susceptibility to the severe forms of the COVID-19, they also tend to develop weake…
Immunosenescence in chronic obstructive pulmonary disease patientsChronic obstructive pulmonary disease (COPD) é a disease characterized by obstruction of airflow, with non-specific and variables clinical features. The worldwilde COPD prevalence has increased due to increased exposure to risk factors as cigarette smoke, biomass exposure, and higher atmospheric pollution. This major exposu…
(Only some records are available in English at this moment)
A esporotricose tem emergido como um relevante problema de saúde pública no Brasil, impulsionado pelo aumento de surtos associados à transmissão zoonótica. A hiperendemia causada por Sporothrix brasiliensis, inicialmente descrita no Rio de Janeiro, já se disseminou por todo o país e alcançou países vizinhos. As espécies patogênicas do gênero Sporothrix apresentam diferenças importantes em…
O projeto visa investigar as variações das espécies de Aspergillus spp. Que causam APC e AIA nos pacientes, além de explorar diferenças na resistência relacionadas a mutações no gene cyp51. Espera-se também descobrir espécies raras nesse contexto desde a realização de testes micológicos na identificação das amostras de Aspergillus spp, assim como amostras de espécies diferentes as encontr…
Pulmonary Aspergillosis, caused by some species of the genus Aspergillus, is considered a severe fungal infection with great clinical relevance. Among the clinical forms of Pulmonary Aspergillosis, Chronic Pulmonary Aspergillosis (APC) is considered one of the most frequent affecting mainly immunocompetent patients. In addition to APC, Acute Invasive Aspergillosis (AIA) is a serious treat…
(Only some records are available in English at this moment)
Vaccines have played a pivotal role in the preservation of lives, surpassing any other medical intervention in terms of efficacy, durability, and safety. However, it is important to note that kidney transplant recipients often exhibit a heightened susceptibility to infections compared to the general population. Many of these patients remain unprotected against diseases that could be preve…
Onychomycosis is the most common nail condition in adults, corresponding to about 50% of all nail diseases. Its prevalence is estimated at 5.5% of the world population and 90% are caused by dermatophyte fungal species, especially Trichophyton rubrum and Trichophyton interdigitale. Despite this, onychomycosis caused by non-dermatophyte molds and mixed infections has been reported more rece…
Candida spp. is responsible for more than 80% of nosocomial infections of fungal origin, representing an important cause of morbidity and mortality. Among species, Candida parapsilosis has been more prevalent in neonatal ICUs, but has recently emerged in adult ICUs. The ability of this pathogen to form biofilm and colonize medical devices and the hands of health professionals favors its h…
(Only some records are available in English at this moment)
Species of the genus Aspergillus spp. are considered fungal microorganisms with the highest frequency of isolation in clinical and environmental samples. These can cause infections in humans, leading to cutaneous and disseminated clinical manifestations, primarily affecting the lungs. The treatment of pulmonary aspergillosis has been carried out with antifungals from the azole class (itra…