Natália Galdi Quel

• Abstract

  The great importance of understanding the interaction of Hsp90 relies on the fact that this chaperone is a 'hub protein' that interacts with at least 10% of the proteins expressed in eukaryotes. Hsp90 interacts with the R2TP system and the Hsp70/Hsp40 system, all of which are involved in genomic and protein homeostasis (proteostasis). Tah1 and Pih1 connect the RVBs, which have helicase fu…

  Study of interactions between chaperome components, BP.PD

• Abstract

  A number of human diseases known as 'conformational' is related to the incorrect protein folding. Misfolded proteins do not function correctly and may also form aggregates or amyloids, which are associated with hundreds of diseases including Alzheimer's and Parkinson's. Molecular chaperones and Hsps (heat shock proteins) participate in a cellular system known as PQC (Protein Quality Contr…

  Characterization of the role of ATPase domains and human co-chaperones Hsp40 and hop in cellular mechanisms of thermal tolerance and suppression of protein aggregation, BP.DR

• Abstract

  Escherichia coli isolated from avian cellulits lesions in broiler chickens produce a cytotoxin called Vat (vacuolating autotransporter toxin)that causes intense vacuolization in avian cells, but not in mammalian cells. Previous studies have shown that Vat induced, in broilers, releasing inflammatory cytokines TNF-± and IL-10. Moreover, histological analysis of lesions induced experimental…

  Vat (vacuolating autotransporter toxin) produced by APEC: internalization, intracellular translocation and cytotoxic activity in avian cells, BP.MS

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