CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Research scientist at The Brazilian Biosciences National Laboratory (LNBio) - Center for Research in Energy and Materials (CNPEM).Bachelor's, Master and PhD degrees in Biomolecular Physics from the University of São Paulo.Post-Doc Fellow at the Laboratory of Molecular Biology - Medical Research Council - UK (LMB-MRC).Experience in Structural Biology and Biophysics. (Source: Lattes Curriculum)
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The enzyme DDX3X is an ATP-dependent RNA helicase from the DEAD-box family that plays a crucial role in RNA metabolism, particularly in neurodevelopmental processes. This protein is composed of two RecA-like domains that form the ATP and RNA binding regions, flanked by flexible N- and C-terminal ends. The hypothesis of this work is that these terminal regions may regulate the enzymatic fu…
DDX3X is an ATP-dependent RNA helicase from the DEAD-box family with an important role in RNA metabolism, being involved in the liquid-liquid phase separation (LLPS) process in the cell. Biomolecular condensation is a new field in Biology involved in membraneless organelles formation such as stress granules, for which DDX3X is essential. DDX3X R534C mutation, located to the ATP binding re…
Centrioles assemble the centrosome, the microtubule organizing centre essential for cell division in proliferating cells. Centrioles also template cilia, cell organelles that act as antenna in quiescent cells and can also generate fluid flow. Because of their essential functions in human life, centrioles are highly regulated throughout the cell cycle. Among the least studied centriole cyc…
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