Abstract
Acute lymphoblastic leukemia (ALL) is characterized by the uncontrolled production of lymphoid blasts and by blocking the production of normal hematopoiesis, and neoplasia is more frequent in children and adolescents. Treatment of the disease is done with L-asparaginase (L-ASNase), an enzyme obtained from the bacteria Escherichia coli and Dickeya chrysanthemi (formerly known as Erwinia ch…