David Zachary Mokry

Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal)
Birthplace: Estados Unidos

Abstract
The maintenance of protein homeostasis is critical for cellular survival, and molecular chaperones are essential for this process. One important protein for facilitating refolding is Hsp90, which also has key roles in a host of other cellular functions, such as proteostasis, epigenetics, telomere maintenance, innate immunity, and biological signaling, among others. Hence, disruption of Hs…
Studies of proteins in the Eukaryotic hsp90 proteomic hub: Functional characterization of the human and Leishmania braziliensis p23 co-chaperones and a possible metazoan hsp100/clpB ortholog utilizing yeast as a surrogate expression system, BP.PD
Abstract
The proper structure of proteins is maintained by a sophisticated system of proteinchaperones. When this system is disrupted, proteins can become unfolded, lose function,and form toxic aggregates that are implicated in a number of different pathologies. Theseaggregates can be eliminated by specialized chaperones that contain a disaggregaseactivity working in conjunction with an Hsp70 syst…
From toxic aggregates to properly folded proteins - Functional characterization of a novel HSP104 ortholog in mammals, and insight into the molecular architecture and substrate specificities of Type I and Type II HSP40S, BP.PD

Source:Lattes Curriculum

CV Lattes

3 / 2	Completed scholarships in Brazil

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Abstract

Abstract