José Xavier Neto

• 8th Meeting of the Latin American Society for Developmental Biology - 2015 LASDB Meeting, AO.R

• Abstract

  Previously, we determined that retinoic acid (RA) signaling synthesized by ALDH1A2/RALDH2 enzyme is crucial for cardiac partition between the units of influx (atria) and efflux (ventricles) in amniote vertebrates. We propose to: 1) investigate the controversial role of RA signaling in teleost to define if RA signaling is, or not, an ancestral mechanism for the partition of the influx/effl…

  The evolutionary origins of regulatory networks that segment the heart into inflow and outflow chambers, AP.R
• ES cells as a model system for embryonic development | São Paulo - SP, AO.R

(Only some records are available in English at this moment)

• Abstract

  The CRISPR/Cas9 technology has recently emerged as an effective alternative for the introduction of site-specific modifications into the genome. Compared to the previously techniques, CRISPR/Cas9 has lower cost, greater efficiency and speed to edit the genome in multiple cell types and organisms. The CRISPR/Cas9 system is based on the use of a small RNA which is able to pair with target D…

  Generation of a knockout mouse for the orphan nuclear receptor Coup-TFII: investigation of the molecular mechanisms underlying the atrial-specific expression of the SMyHC3 gene, BP.PD

• Abstract

  The cardiac development is a complex process with different pathways. In this project we intent to validate protein-protein interactions that were identified by mass spectrometry and that are likely related to the development of the heart inflow tract (sinus venosus and atrium). Previously, our group identified regulatory elements, controlling atrial-specific expression of SMyHC III promo…

  Identification of genetic networks interacting with COUP-TF II to determinate the atrial cardiac cells identity by the SMyHC III promoter, BP.DD

• Abstract

  This project represents an extension of the paradigms that we created from our molecular simulation studies to understand the frequent structure and function changes of Aldehyde Dehydrogenases (ALDH) during evolution. The ALDHs form a superfamily of proteins that catalyze the oxidation of several aldehydes, but the evolutionary origins of their substrate preference are unknown. Despite ha…

  Studies of structure and function of aldehyde dehydrogenases involved in cellular signaling pathways and detoxification, BP.DD

(Only some records are available in English at this moment)

• Abstract

  Cardiac development is a complex process that requires various morphogenetic movements and multiple gene regulatory networks. Numerous molecular processes organize the embryonic heart tube into functional units of inflow (atria) and outflow (ventricles) but the mechanisms of chamber expression are still incompletely understood. Only a handful of cardiac genes are known to be expressed in …

  Atrial selectivity from a complex nuclear receptor driven by androgen receptor: a novel gene regulatory network, BE.EP.DD
• Molecular regulation of axial skeletal muscle patterning during mouse embryogenesis, BE.PQ