José Xavier Neto
CV Lattes
Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Universidade Federal do Ceará (1989) and doctorate at Physiology from Universidade de São Paulo (1993). Has experience in Morphology, focusing on Embryology, acting on the following subjects: retinoic acid, raldh2, development, heart and hemorrhage. (Source: Lattes Curriculum)
- 8th meeting of the Latin American society for developmental biology - 2015 LASDB meeting, AO.R
- The evolutionary origins of regulatory networks that segment the heart into inflow and outflow chambers, AP.R
Abstract
Previously, we determined that retinoic acid (RA) signaling synthesized by ALDH1A2/RALDH2 enzyme is crucial for cardiac partition between the units of influx (atria) and efflux (ventricles) in amniote vertebrates. We propose to: 1) investigate the controversial role of RA signaling in teleost to define if RA signaling is, or not, an ancestral mechanism for the partition of the influx/ef...
- ES cells as a model system for embryonic development | São Paulo - SP, AO.R
(Only some records are available in English at this moment)
- Identification of genetic networks interacting with COUP-TF II to determinate the atrial cardiac cells identity by the SMyHC III promoter, BP.DD
Abstract
The cardiac development is a complex process with different pathways. In this project we intent to validate protein-protein interactions that were identified by mass spectrometry and that are likely related to the development of the heart inflow tract (sinus venosus and atrium). Previously, our group identified regulatory elements, controlling atrial-specific expression of SMyHC III pro...
- Generation of a knockout mouse for the orphan nuclear receptor Coup-TFII: investigation of the molecular mechanisms underlying the atrial-specific expression of the SMyHC3 gene, BP.PD
Abstract
The CRISPR/Cas9 technology has recently emerged as an effective alternative for the introduction of site-specific modifications into the genome. Compared to the previously techniques, CRISPR/Cas9 has lower cost, greater efficiency and speed to edit the genome in multiple cell types and organisms. The CRISPR/Cas9 system is based on the use of a small RNA which is able to pair with target...
- Studies of structure and function of aldehyde dehydrogenases involved in cellular signaling pathways and detoxification, BP.DD
Abstract
This project represents an extension of the paradigms that we created from our molecular simulation studies to understand the frequent structure and function changes of Aldehyde Dehydrogenases (ALDH) during evolution. The ALDHs form a superfamily of proteins that catalyze the oxidation of several aldehydes, but the evolutionary origins of their substrate preference are unknown. Despite ...
- Study on the molecular mechanisms of the orphan nuclear receptor COUP-TFII action during cardiac chambers development, BP.PD
Abstract
The embryonic development integrates different levels of organization that are activated and distributed during the events of cell specialization in tissues and organs. Over the past 14 years, our group has generated strong evidence that retinoic acid (RA) signaling is essential for the specification of cardiac progenitor cells in anterior and posterior domains, which give rise to ventr...
(Only some records are available in English at this moment)
- Atrial selectivity from a complex nuclear receptor driven by androgen receptor: a novel gene regulatory network, BE.EP.DD
Abstract
Cardiac development is a complex process that requires various morphogenetic movements and multiple gene regulatory networks. Numerous molecular processes organize the embryonic heart tube into functional units of inflow (atria) and outflow (ventricles) but the mechanisms of chamber expression are still incompletely understood. Only a handful of cardiac genes are known to be expressed i...
- Molecular regulation of axial skeletal muscle patterning during mouse embryogenesis, BE.PQ
| 12 / 8 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 19 / 5 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 34 / 16 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 7 |
| Citations | 163 |
| Cit./Article | 23.3 |
| Data from Web of Science | |
SIMÕES-COSTA, MARCOS S.; VASCONCELOS, MICHELLE; SAMPAIO, ALLYSSON C.; CRAVO, ROBERTA M.; LINHARES, VANIA L.; HOCHGREB, TATIANA; YAN, CHAO Y. I.; DAVIDSON, BRAD; XAVIER-NETO, JOSÉ. The evolutionary origin of cardiac chambers. Developmental Biology, v. 277, n. 1, p. 1-15, Jan. 2005. (01/00009-0)
PAVAN, MARILENE; RUIZ, VIVIANE F.; SILVA, FABIO A.; SOBREIRA, TIAGO J.; CRAVO, ROBERTA M.; VASCONCELOS, MICHELLE; MARQUES, LIVIA P.; MESQUITA, SONIA M. F.; KRIEGER, JOSE E.; LOPES, ANTONIO A. B.; et al. ALDH1A2 (RALDH2) genetic variation in human congenital heart disease. BMC MEDICAL GENETICS, v. 10, NOV 3 2009. Web of Science Citations: 22. (01/00009-0)
AZAMBUJA, ANA P.; PORTILLO-SANCHEZ, VICTOR; RODRIGUES, MARILIZA V.; OMAE, SAMANTHA V.; SCHECHTMAN, DEBORAH; STRAUSS, BRYAN E.; COSTANZI-STRAUSS, EUGENIA; KRIEGER, JOSE E.; PEREZ-POMARES, JOSE M.; XAVIER-NETO, JOSE. Retinoic Acid and VEGF Delay Smooth Muscle Relative to Endothelial Differentiation to Coordinate Inner and Outer Coronary Vessel Wall Morphogenesis. Circulation Research, v. 107, n. 2, p. 204-U87, JUL 23 2010. Web of Science Citations: 34.
ALVARES, LUCIA ELVIRA; WINTERBOTTOM, FARRAH LEIGH; SOBREIRA, DEBORA RODRIGUES; XAVIER-NETO, JOSE; SCHUBERT, FRANK RICHARD; DIETRICH, SUSANNE. Chicken Dapper Genes Are Versatile Markers for Mesodermal Tissues, Embryonic Muscle Stem Cells, Neural Crest Cells, and Neurogenic Placodes. DEVELOPMENTAL DYNAMICS, v. 238, n. 5, p. 1166-1178, MAY 2009. Web of Science Citations: 8.
XAVIER-NETO, JOSE; SOUSA COSTA, ANGELA M.; FIGUEIRA, ANA CAROLINA M.; CAIAFFA, CARLO DONATO; DO AMARAL, FABIO NEVES; CERQUEIRA PERES, LARA MALDANIS; PIRES DA SILVA, BARBARA SANTOS; SANTOS, LUANA NUNES; MOISE, ALEXANDER R.; CASTILO, HOZANA ANDRADE. Signaling through retinoic acid receptors in cardiac development: Doing the right things at the right times. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, v. 1849, n. 2, SI, p. 94-111, FEB 2015. Web of Science Citations: 26. (13/12008-6, 12/14859-0, 11/15273-7)
CASTILLO, HOZANA A.; CRAVO, ROBERTA M.; AZAMBUJA, ANA P.; SIMOES-COSTA, MARCOS S.; SURA-TRUEBA, SYLVIA; GONZALEZ, JOSE; SLONIMSKY, ESFIR; ALMEIDA, KARLA; ABREU, JOSE G.; AFONSO DE ALMEIDA, MARCIO A.; et al. Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer. DEVELOPMENT, v. 137, n. 3, p. 507-518, FEB 1 2010. Web of Science Citations: 15.
SOBREIRA, TIAGO J. P.; MARLETAZ, FERDINAND; SIMOES-COSTA, MARCOS; SCHECHTMAN, DEBORAH; PEREIRA, ALEXANDRE C.; BRUNET, FREDERIC; SWEENEY, SARAH; PANI, ARIEL; ARONOWICZ, JOCHANAN; LOWE, CHRISTOPHER J.; et al. Structural shifts of aldehyde dehydrogenase enzymes were instrumental for the early evolution of retinoid-dependent axial patterning in metazoans. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 108, n. 1, p. 226-231, JAN 4 2011. Web of Science Citations: 36.
HOCHGREB‚ T.; LINHARES‚ V.L.; MENEZES‚ D.C.; SAMPAIO‚ A.C.; YAN‚ C.Y.I.; CARDOSO‚ W.V.; ROSENTHAL‚ N.; XAVIER-NETO‚ J.. A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. DEVELOPMENT, v. 130, n. 22, p. 5363-5374, 2003. (01/00009-0)
XAVIER-NETO, JOSE; CARVALHO, MURILO; PASCOALINO, BRUNO DOS SANTOS; CARDOSO, ALISSON CAMPOS; SOUSA COSTA, ANGELA MARIA; MACEDO PEREIRA, ANA HELENA; SANTOS, LUANA NUNES; SAITO, ANGELA; MARQUES, RAFAEL ELIAS; COSTA SMETANA, JULIANA HELENA; et al. Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study. PLoS Neglected Tropical Diseases, v. 11, n. 2, FEB 2017. Web of Science Citations: 22. (13/22695-0)