Abstract
Neurocryptococcosis is a subacute meningoencephalitis caused by the fungus Cryptococcus spp., occurring most commonly in patients diagnosed with HIV or other forms of immunosuppression. Amphotericin B (AnfB), the drug of choice for the treatment of neurocryptococcosis, has low permeability in the blood-brain barrier (BBB), with consequent low concentrations in the cerebrospinal fluid (CSF…