CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Ph.D. in Molecular Biology by Escola Paulista de Medicina, Unifesp (1975), Bachelor in Biomedical Sciences by Escola Paulista de Medicina (1971), and Bachelor in Biological Sciences by Universidade de São Paulo (1971). Pos-Doc at Baylor College of Medicine (1979). Is Livre Docente (1996) in Molecular Biology, and a Full Professor Molecular Biology, Department of Biochemistry, Escola Paulista de Medicina, Unifesp. Is expert in Biochemistry and Molecular Biology, focusing Glycoconjugates of the Extracellular Matrix, both normal and in diseases, such as joint diseases and diabetes mellitus. (Source: Lattes Curriculum)
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Diabetic nephropathy is a microangiopathy that affects about 100 million of diabetic patients worldwide. The first clinical sign of diabetic nephropathy is microalbuminuria that may evolve to end stage renal disease. For sulfated polysaccharides (glycosaminoglycans - GAGs - and dextran sulfate), in contrast to proteins, an early and important decrease in urinary excretion occurs in diabet…
A hallmark in diabetes mellitus is microangiopathy, with capillary basement membrane thickening and loss of normal function in capillary bed. Although these changes occur in all tissues, many studies focus the kidney because the glomerulus contain abundant and concentrated capillar basement membrane, and also because diabetic nephropathy is one of the most serious and frequent consequence…
Proteoglycans (PGs) are macromolecules widely distributed in animal tissues. They are important components of extracellular matrix and cell surface. PG degradation occurs mainly in lysosomes after endocytosis, by the action of proteases and endoglycosidases. These enzymes act upon the protein core and the glycosaminoglycan (GAG) side chains, respectively. Smaller fragments of GAGs are deg…
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