CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Farmacêuticas from Pontifícia Universidade Católica de Campinas (2009), master's at Cancerology from Fundação Antônio Prudente (2012) and doctorate at Cancerology from Fundação Antônio Prudente (2014). Has experience in Biochemistry, acting on the following subjects: glioblastoma, sperm, rab7, stat3 and sperm bank. (Source: Lattes Curriculum)
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The human HTRA1 enzyme (High-Temperature Requirement protein A1, Q92743 Uniprot) is a 51 kDa non-glycosylated serine protease located primarily in the extracellular environment. This enzyme is involved in the remodeling of the extracellular matrix (ECM) by degrading its components, such as decorim, fibronectin, aggrecam and collagen. The mode of action of HTRA1 is related to its serine pr…
Glioblastoma Multiforme (GBM) is the type of glial tumor most common and aggressive. Identifying molecules associated with tumor progression might lead to development of new drugs for the treatment of GBM. During the Masters, using tissue microarrays showed that human GBMs exhibit higher expression of STI1/Hop, and that this location has predominantly nuclear when compared to non-neoplast…
Gliomas are tumors derived from glial cells and from their precursors in the CNS. The most common type is the Glioblastoma Multiform (GBM) that presents a devastating malign progression. The proliferation mechanisms and the invasion of this tumor are complex and may involve the signal transduction pathways deregulation. Several molecular targets involved in this pathway were investigated …
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