CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências e Tecnologias para a Sustentabilidade (CCTS) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciencias Biologicas from Pontifícia Universidade Católica de Campinas (1990), master's at Biochemistry from Universidade de São Paulo (1992) and doctorate at Biochemistry from Universidade de São Paulo (1996). He is currently coordenador do curso de pós-graduação at Universidade Federal de São Carlos. Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: bioluminescencia, luciferases, lampyridae, phengodidae and elateridae. (Source: Lattes Curriculum)
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Firefly luciferases catalyze the efficient production of yellow-green light under physiological conditionsnormal, having been widely used for bioanalytical purposes for more than 5 decades. However, under conditionsacids, high temperatures and the presence of heavy metals, they produce red light, a property calledpH sensitivity. Despite the demand for physiological intracellular biosensor…
Bioluminescence, the emission of cold, visible light by luciferin-luciferase reactions of certain organisms, has been used for several decades for bioanalytical purposes in scientific research, medical, industrial and environmental analysis. Luciferase enzymes from fireflies and their genes are used as luminescent reagents in kits, bioluminescent probes for cell labeling, biosensors, to a…
Bioluminescence, the emission of cold light by living organisms, has been the subject of many multidisciplinary studies involving physics, chemistry and biology, resulting in important scientific discoveries and biotechnological applications in the last century. It can be considered as one of the signatures of life, and for this reason has been used as an excellent bioindicator at the mol…
Bioluminescence, the emission of cold light by living organisms, has been the subject of many multidisciplinary studies involving physics, chemistry and biology, resulting in important scientific discoveries and biotechnological applications in the last century. It can be considered as one of the signatures of life, and for this reason has been used as an excellent bioindicator at the mol…
Not only is the elucidation of the Orfelia system likely to enable new bioanalytical tools, this bilateral project is also expected to benefit both the research gropps and associated graduate programs of Vanderbilt University and the Federal University of São Carlos, with the exchange of qualified human resources in the field of bioluminescent applications. (AU)
Bioluminescence in insects is found mainly in Coleoptera and Diptera. In Beetles of the superfamily Elateroidea, bioluminescence involves the same bioluminescence system with luciferins and luciferases well characterized. Beetle luciferin is a benzothiazolic compound, however, its biosynthetic origin remains unknown. The lanterns of bioluminescent beetles probably evolved from extensions …
(Only some records are available in English at this moment)
Firefly luciferases are sensitive to pH, temperature and heavy metals, ranging from green to red. In recent years, it has been demonstrated that this sensitivity can be used analytically to determine intracellular pH and in sensors and assays for heavy metals such as mercury and cadmium. However, it is still unknown whether this enzymatic sensitivity actually has some biological function …
Bioluminescence in the terrestrial environment occurs mainly in coleoptera of the superfamily Elateroidea, which includes 4 families: Elateridae, Lampyridae, Phengodidae and Rhagophthalmidae. The Lampyridae family is the richest in bioluminescent species, with around 100 genera and more than 2,000 species described around the globe. The Neotropical fauna of these coleoptera is the richest…
Bioluminescence, the emission of cold light by organisms for the purpose of biological communication, has been used for bioanalytical purposes for several decades. The beetle luciferin-luciferase system is certainly the most used, being used as bioanalytical reagents, and the genes that encode its luciferases as reporters of biological and pathological processes, such as gene expression, …
Immunoassays are widely used in biomedical analyzes based on antigenantibody interaction, in which they are capable of detecting antibodies against specific antigens. In general, these assays mainly use chemiluminescence as a detection method, due to its sensitivity. However, current chemiluminescence methods based on conjugated HRP show a rapid decay of luminescence. Thus, the new fusion…
Bioluminescence, the light emission in living organisms for signaling purposes, has several biotechnological and multidisciplinary applications. Luciferases are the responsible enzymes for catalyzing the light emission through the substrates oxidation (luciferins). In insects, bioluminescence is found in only three orders: Collembola, Diptera and Coleoptera. The bioluminescent system best…
(Only some records are available in English at this moment)
Beetle luciferases are responsible for the production of different bioluminescence colors from green to red using the same firefly D-luciferin. Some luciferin analogues such as 6´amino-analogues can extend the range of bioluminescence colors. Among several beetle luciferases that have cloned and been studied, Phrixothrix hirtus (PxRE) railroadworm luciferase is still the only one that nat…
Bioluminescence, the light emission produced by living organisms, has been widely found in terrestrial habitats in Elateroidea superfamily. The mechanism of light production in this superfamily is well known, however studies about genome organization and size are not discussed yet. The functional genomic projects are helping to identify important structural and functional elements of geno…
Bioluminescence, the emission of visible light by living organisms, is widely used in biosensors. Firefly luciferases genes are among the most used reporter genes in bioluminescent biosensors. Firefly luciferases are pH-sensitive displaying a large red shift at acid pH, a property that has been considered a useless for most applications. However, currently intracellular pH-biosensors are …
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 15 / 13 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 39 / 30 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 66 / 55 | All research grants and scholarships |
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