CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences at UNESP-Botucatu (São Paulo State University Júlio de Mesquita Filho). He completed his master's and doctorate at the Department of Morphology and Genetics - UNIFESP, with a focus on Psychiatric Genetics and large-scale genomic analysis. During his PhD, he conducted a 1-year research internship at the MRC - Social, Genetics & Developmental Psychiatry Center at Kings College London, where he improved his training in bioinformatics and large-scale genetic and epigenetic data analysis. He has a postdoctoral fellow at the Department of Psychiatry at UNIFESP in which he investigated the transcriptome and polygenic risk score for a longitudinal cohort of children and adolescents at risk for psychiatric disorders. During his postdoctoral studies, he worked as a visiting researcher for 1 year at the Broad Institute of Harvard and MIT and at Massachusetts General Hospital with a FAPESP scholarship, investigating new approaches to apply the polygenic risk score in admixed populations. He was a visiting professor at the Graduate Program in Structural and Functional Biology at UNIFESP from 11/2019 to 11/2021. He is Assistant Professor at the Molecular Biology Division in the Department of Biochemistry - UNIFESP. His main areas of expertise are bioinformatics, genetics and molecular biology, with a focus on risk markers for psychiatric diseases, including polygenic risk scoring and epigenetic regulation by miRNAs. (Source: Lattes Curriculum)
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Mental disorders are one of the leading causes of years of life lost due to disability. Psychiatric symptoms usually begin during adolescence and may progress and persist into adulthood. Despite advances and investments, Genome Wide Association Studies (GWAS) are only able to explain 1/4 of the total heritability, and it is believed that the remaining heritability may be explained by gene…
Psychiatric disorders (PD) are one of the main causes of years lost due to disability due to their early onset and severity of symptoms, which can persist and impact mental health until adulthood. Thus, projects dedicated to studying the etiology and pathophysiology of PDs since childhood have the potential to enable preventive approaches and generate ideas for new therapeutics procedures…
Schizophrenia is a severe mental disease with a prevalence of up to 1% in the world population and one of the main causes of disability in developed countries. Schizophrenia is a multifactorial disease and heritability is around 0,8. This suggests that the genome contains a large amount of information that has the potential to be used as genetic markers for diagnosing these disease. Howev…
(Only some records are available in English at this moment)
Schizophrenia is a severe mental disease with a prevalence of up to 1% in the world population and one of the main causes of disability in developed countries. Schizophrenia is a multifactorial disease and heritability is around 0,8. This suggests that the genome contains a large amount of information that has the potential to be used as genetic markers for diagnosing these diseases. In t…
Psychiatric disorders (PDs) are one of the main causes of life years lost due to disability (DALYs - Disability-Adjusted Life Years). Symptoms usually start during late childhood and adolescence, and may persist during adulthood. PDs have a complex and multifactorial inheritance with influence of genetic and environmental factors. As PDs are complex diseases, longitudinal approaches are n…
The objectives of this proposal are a) to improve and b) apply the polygenic risk score (PRS) to our sample of children and adolescents at risk for psychiatric disorders (PDs), c) to characterize the gene expression profile in this sample and d) compile and associate the genomic and transcriptomic results. For the PRS analysis, we will use the already genotyped samples (N = 750). For the …
(Only some records are available in English at this moment)
microRNAs (miRNAs) have a role in regulating processes that may lead to the development of psychiatric disorders. Alterations in miRNA expression could be mediated by expression quantitative trait loci (eQTLs). However, since eQTLs are genomic information, ancestry may influence the frequency of these variants, especially important to consider in populations that have a high degree of adm…
This study aims to characterize the admixture of a longitudinal cohort of children and adolescents (Instituto Nacional da Psiquiatria do Desenvolvimento - INPD) and understand how ancestry influences the polygenic risk scores (PRS) of psychiatric disorders (PDs) in this cohort. Besides, we will simulate latin american genotypes in order to find which is the best reference panel to charact…
The investigation of individuals during their first-episode psychosis (FEP), before the progression and the treatment with antipsychotic medications, is helpful for understanding the complexity of schizophrenia. Considering that schizophrenia is a chronic condition, disease progression and use of antipsychotic medication can confound results on gene expression and DNA methylation. Our mai…
| 4 / 4 | Ongoing scholarships in Brazil |
| 6 / 5 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
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