CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences at UNESP-Botucatu (São Paulo State University Júlio de Mesquita Filho). He completed his master's and doctorate at the Department of Morphology and Genetics - UNIFESP, with a focus on Psychiatric Genetics and large-scale genomic analysis. During his PhD, he conducted a 1-year research internship at the MRC - Social, Genetics & Developmental Psychiatry Center at Kings College London, where he improved his training in bioinformatics and large-scale genetic and epigenetic data analysis. He has a postdoctoral fellow at the Department of Psychiatry at UNIFESP in which he investigated the transcriptome and polygenic risk score for a longitudinal cohort of children and adolescents at risk for psychiatric disorders. During his postdoctoral studies, he worked as a visiting researcher for 1 year at the Broad Institute of Harvard and MIT and at Massachusetts General Hospital with a FAPESP scholarship, investigating new approaches to apply the polygenic risk score in admixed populations. He was a visiting professor at the Graduate Program in Structural and Functional Biology at UNIFESP from 11/2019 to 11/2021. He is Assistant Professor at the Molecular Biology Division in the Department of Biochemistry - UNIFESP. His main areas of expertise are bioinformatics, genetics and molecular biology, with a focus on risk markers for psychiatric diseases, including polygenic risk scoring and epigenetic regulation by miRNAs. (Source: Lattes Curriculum)
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Mental Disorders (MDs) are multifactorial diseases and have heritability between 20% and 80%. This suggests that the genome contains a large amount of information with the potential to be used as a genetic risk marker for MDs. However, the polygenic nature of these diseases, added to the influence of dynamic environmental factors, makes it harder to investigate this information. The expan…
The development of mental disorders (MDs) is greatly influenced by genetic and environmental factors. The genetic variants involved in the progression of these disorders range in size, from single nucleotide variants (SNVs) to large structural variants, such as copy number variations (CNVs). New genomic technologies, such as whole genome sequencing (WGS), allow for a better understanding …
Psychiatric disorders are one of the main causes of years of life lost due to disability. Symptoms often begin during adolescence and can progress and persist into adulthood. As they are multifactorial phenotypes, environmental and genetic risk factors contribute to their establishment. Among genetic risk factors, common variants (SNVs) are currently the most used to predict the risk of m…
Psychiatric disorders affect around 12% of the world's population and are among the leading causes of Disability-adjusted life years. Eating disorders (ED) and obsessive-compulsive disorder (OCD) are examples of psychiatric disorders that show a high degree of correlation and genetic overlap. The high heritability of Anorexia Nervosa, a major type of ED, and OCD suggests that the genome c…
(Only some records are available in English at this moment)
Mental disorders are one of the leading causes of years of life lost due to disability. Psychiatric symptoms usually begin during adolescence and may progress and persist into adulthood. Despite advances and investments, Genome Wide Association Studies (GWAS) are only able to explain 1/4 of the total heritability, and it is believed that the remaining heritability may be explained by gene…
Schizophrenia is a severe mental disease with a prevalence of up to 1% in the world population and one of the main causes of disability in developed countries. Schizophrenia is a multifactorial disease and heritability is around 0,8. This suggests that the genome contains a large amount of information that has the potential to be used as genetic markers for diagnosing these disease. Howev…
Schizophrenia is a severe mental disease with a prevalence of up to 1% in the world population and one of the main causes of disability in developed countries. Schizophrenia is a multifactorial disease and heritability is around 0,8. This suggests that the genome contains a large amount of information that has the potential to be used as genetic markers for diagnosing these diseases. In t…
(Only some records are available in English at this moment)
The psychiatric disorders (PD) are among the 10 main causes of years of life lost due to disability. Schizophrenia (SCZ) is one of the most heritable PDs, with a heritability of ~0.8. The main aspects of SCZ can be divided into dimensions of positive symptoms (psychosis), negative symptoms and cognitive deficits. The large-scale genome-wide association study (GWAS) is a type of explorator…
microRNAs (miRNAs) have a role in regulating processes that may lead to the development of psychiatric disorders. Alterations in miRNA expression could be mediated by expression quantitative trait loci (eQTLs). However, since eQTLs are genomic information, ancestry may influence the frequency of these variants, especially important to consider in populations that have a high degree of adm…
This study aims to characterize the admixture of a longitudinal cohort of children and adolescents (Instituto Nacional da Psiquiatria do Desenvolvimento - INPD) and understand how ancestry influences the polygenic risk scores (PRS) of psychiatric disorders (PDs) in this cohort. Besides, we will simulate latin american genotypes in order to find which is the best reference panel to charact…
The investigation of individuals during their first-episode psychosis (FEP), before the progression and the treatment with antipsychotic medications, is helpful for understanding the complexity of schizophrenia. Considering that schizophrenia is a chronic condition, disease progression and use of antipsychotic medication can confound results on gene expression and DNA methylation. Our mai…
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 18 / 17 | All research grants and scholarships |
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