CV Lattes
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Universidade de Mogi das Cruzes (UMC). Campus da Sede Mogi das Cruzes. Pró-Reitoria Acadêmica (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciencias Biológicas Modalidade Médica from Universidade Federal de São Paulo (1993), master's at BILOGIA MOLECULAR from Universidade Federal de São Paulo (2000) and ph.d. at BIOLOGIA MOLECULAR from Universidade Federal de São Paulo (2004). Has experience in Biochemistry, focusing on Enzymology, acting on the following subjects: cysteine proteinase, leishmania mexicana, cruzain, fluorogenic substrates and cruzipain. (Source: Lattes Curriculum)
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Cathepsins B and L, cysteine lysosomal proteases, are important targets in the development of a variety of therapeutic agents due to the involvement of these proteases in various disease conditions. They are associated with cancer progression due to the degradation capacity of the extracellular matrix, facilitating invasion, angiogenesis and metastasis, in addition to favoring viral repli…
Proteases are involved in many physiological processes attending to the metabolic and functional demand of the organisms to which they participate. However, in many situations these same proteases can trigger unwanted processes that establish pathologies in humans. Therefore, the modulation of its activities is a way of controlling its actions in pathogenic mechanisms such as tumor progre…
The protein-convertases (PCs) are proteolytic enzymes that belong to the family of subtilisin-like serine proteases. These enzymes are found in the secretory pathways and in secretory vesicles of trans-Golgi in the eukaryotic cell and they are involved in the processing of pro-proteins, pro-hormones, receptors, and pro-viral capsid proteins. Convertases are Ca2+-dependent endopeptidases t…
(Only some records are available in English at this moment)
This research project aims to investigate the influence of heparin on the inhibition of cathepsins B and L by various compounds, including chalcone derivatives, flavonoids, palladium complexes, and aminothiazoles. These proteolytic enzymes play critical roles in protein degradation and cellular regulation and are frequently implicated in the progression of diseases such as cancer. Under p…
Cathepsins B and L, cysteine lysosomal proteases, are significant targets in the development of a variety of therapeutic agents due to their involvement in various disease conditions. They are associated with cancer progression due to their ability to degrade the extracellular matrix, facilitating invasion, angiogenesis, and metastasis, as well as promoting viral replication in human cell…
Leishmaniasis are pathologies considered neglected by the World Health Organization, approximately 70 countries are part of the endemic region of the disease, but it is worth mentioning that the most affected are tropical and subtropical. Although developed countries report cases, underdeveloped or developing countries are the most affected due to poor health status, since the females of …
The catalytic mechanism of serine proteases is based on the catalytic triad of the active site, consisting of three invariable amino acids: serine, which acts as a nucleophilic group, aspartate, and histidine as an electrophilic group acting as a base. In eukaryotes, several proteins that pass through the secretory pathway are synthesized as pro-proteins undergo endo-or exo-proteolysis. A…
(Only some records are available in English at this moment)
| 5 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 6 / 4 | Completed scholarships in Brazil |
| 12 / 9 | All research grants and scholarships |
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