CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Associate Professor in the Department of Pharmacology at the Ribeirão Preto Medical School, University of São Paulo. He holds a degree in Pharmacy from the School of Pharmacy and Biochemistry at the Federal University of Juiz de Fora (2008) and a Master's (2009-2011) and Ph.D. (2011-2015) in Biological Sciences (Pharmacology) from the Ribeirão Preto Medical School, University of São Paulo. He was a postdoctoral fellow in Dr. Anthony Grace's laboratory at the University of Pittsburgh (May 2015 - July 2018). Currently a member of the Hispanic/Latin American Committee of the American College of Neuropsychopharmacology (ACNP). He received the 2020 SIRS Global Schizophrenia Award and the 2025 SIRS Rising Star Award, both from the Schizophrenia International Research Society (SIRS). His current research focuses on the (dys)regulation of the dopaminergic system, stress as a risk factor for schizophrenia development, and new pharmacological targets for schizophrenia treatment. (Source: Lattes Curriculum)
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Studies suggest that trauma during adolescence, a critical period of neurodevelopment, acts as a risk factor for the development of psychiatric disorders. Microglia, the resident immune cells of the central nervous system, appear to play an important role in mediating the response to exposure to traumatic events. Microglia activation can have both protective and harmful effects, depending…
Stress is a risk factor for the development of psychiatric disorders including schizophrenia and depression. The available treatments are insufficient due to their low efficacy and significant adverse effects. In this sense, new pharmacological approaches have been widely studied. Our research group has been investigating the therapeutic potential of cannabidiol (CBD) for years. CBD, like…
In addition to sharing the exposure to stressful events as a common risk factor, depression and schizophrenia also share many of the genetic variations associated with these psychiatric disorders. However, they differ in the mean age of diagnosis. While schizophrenia is usually diagnosed in late adolescence/early adulthood (18-25 years), depression seems to be more common in adults (25-45…
(Only some records are available in English at this moment)
The excitatory-inhibitory (E/I) balance refers to the equilibrium between excitatory and inhibitory neuronal interactions in the central nervous system. This regulated state is crucial for the temporal control and synchronization of neural activity. Among the neurons involved in maintaining this balance, parvalbumin (PV)-expressing GABAergic interneurons play an important role. These inte…
Autism Spectrum Disorder (ASD) is a set of conditions associated with neurodevelopment and is characterized by social impairment and the presence of repetitive and stereotyped behaviors. The etiology of ASD is still unknown; however, it is proposed that the interaction of genetic and environmental factors may be related to the development of the disorder, as well as exposure to medication…
Depression and schizophrenia share stress as a risk factor, but the age of diagnosis specifically sets them apart. While schizophrenia is typically diagnosed in late adolescence, depression is more prevalent in adults. Stress plays a pivotal role in the development of psychiatric disorders, but the neurobiological mechanisms underlying stress susceptibility remain not fully understood. Ke…
(Only some records are available in English at this moment)
Evidence point to changes in the excitatory-inhibitory balance in different psychiatric disorders, such as depression, anxiety, and schizophrenia. This imbalance seems to result from the functional loss of GABAergic interneurons expressing parvalbumin in different brain regions, including the ventral hippocampus, leading to increased activity of glutamatergic pyramidal neurons. Thus, ther…
Evidence indicates that functional impairments of parvalbumin (PV)-containing GABAergic interneurons underlie symptoms of several psychiatric disorders, including schizophrenia and depression. The functional loss of PV interneurons has been associated with redox dysregulation. Due to their high energy demand to maintain their fast-spiking activity, PV interneurons are thought to be more s…
(Only some records are available in English at this moment)
Autism Spectrum Disorders (ASD) are a group of neurodevelopmental disorders that share behavioral alterations in the domains of social interaction, communication and repetitive or stereotyped behavior patterns. The idea that imbalances in dopaminergic neurotransmission in specific brain regions can lead to behavioral alterations similar to those observed in individuals with ASD has been e…
Rostral ventromedial medulla (RVM) is a key structure of the descending pain pathway. Our group described a novel function of the RVM on stress-induced behavioral impairments. We also described a novel projection targeting RVM neurons originating from the lateral habenula (LHb), a structure that works as a relay station interconnecting the limbic forebrain with stress-related monoaminergi…
The onset of some psychiatric disorders, such as schizophrenia, anxiety disorders, and depression, often occurs in late adolescence/early adulthood, which is a period of greater vulnerability to adverse socioenvironmental factors. Evidence suggests that socioenvironmental factors, such as trauma, psychosocial stress, along with genetic predisposition, may increase the individual's suscept…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
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| 5 / 5 | Ongoing scholarships in Brazil |
| 9 / 9 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 23 / 23 | All research grants and scholarships |
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