Gustavo Arantes Rosa Maciel

• Abstract

  Objective: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrinopathy, which etiology encompasses complex genetic traits associated with epigenetic factors, including differences in microRNA (miRNA) expression in a variety of tissues. The circulating form of these molecules is raising attention in the syndrome not only as potential biomarkers of PCOS but also as possible therapeut…

  Avaliação de miRNAs circulantes em mulheres brasileiras com Sindrome dos Ovários Policisticos: Um estudo preliminar, PUB.ART

• Abstract

  Polycystic ovary syndrome (PCOS) is a complex disorder presenting reproductive and metabolic consequences. It has been associated with insulin resistance and hyperinsulinemia, which are responsible for the increase in metabolic risk and type II diabetes. However, it is estimated that 25-50% of PCOS patients do not present such abnormalities, demonstrating the heterogeneity of the syndrome…

  Evaluation of Plasmatic miRNA and Metabolomic Profiles in Polycystic Ovary Syndrome Women, AP.R

• Abstract

  Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women in reproductive age. Metformin and physical exercise are commonly prescribed for PCOS treatment; however their action mechanisms are not fully understood. In this sense, the using of animal models may help in the better understanding of therapeutic strategies and PCOS pathophysiology. The aim of this study is …

  Effects of metformin and physical activity on the hypothalamus, pituitary and ovary of rat model of polycystic ovary syndrome, AP.R

(Only some records are available in English at this moment)

• Abstract

  Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women in reproductive age, impacting 5-10% of premenopausal American women. Although the etiology of PCOS is not entirely clear, it is well known that hyperandrogenism, chronic anovulation and polycystic ovaries are the syndrome main characteristics. It is commonly associated to metabolic disorders such as insuli…

  Effects of metformin and exercise, isolated or associated, on the adipocytes and on the levels of adipose tissue fibrosis in polycystic ovary syndrome rat models, BP.IC

• Abstract

  Polycystic Ovary Syndrome (PCOS) has been associated with insulin resistance, hypertension and dyslipidemia, which are responsible for the increase in cardiovascular risk. However, a subgroup of patients does not present these metabolic disturbances, being classified as 'metabolic health'. Studies with the objective to differentiate such patients from the ones with metabolic compromising …

  Assessment of microRNAs and metabolites plasma profiles in patients with Polycystic Ovary Syndrome, BP.DD

• Abstract

  Polycystic ovary syndrome (PCOS) is a complex disorder of unknown etiology, which is the leading cause of female infertility. It is characterized by hyperandrogenism, amenorrhea and the presence of polycystic ovaries. Regarding the hormonal profile typical of the syndrome, it displays a predominance of the secretion of luteinizing hormone (LH) in relation to follicle-stimulating hormone (…

  Gene expression of insulin receptor in the hypothalamus of female rat in model of Polycystic Ovary Syndrome induced by sexual steroids, BP.IC

(Only some records are available in English at this moment)