Abstract
The Klotho protein has anti-aging function, and Klotho knockout mice (Kl-/-) showed a premature aging phenotype syndrome characterized by arteriosclerosis, osteoporosis, skin atrophy, cognitive decline and pulmonary emphysema. This syndrome can be reversed by restoring Klotho levels. Thus, the kl (-/-) is considered as a model of accelerated aging and it can provide important information …