Abstract
The earlier descriptions of Parkinson's disease (PD) were limited to its motor manifestations: tremor, rigidity, and flexed posture. Years later, a cytoplasmatic inclusion was discovered, the Lewy bodies (LB), the main pathological feature of the disease. The neostriatal dopamine deficiency in PD was only noted later. PD is defined by the progressive degeneration of dopaminergic neurons o…