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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Is the COL5A1 rs12722 Gene Polymorphism Associated with Running Economy?

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Author(s):
Bertuzzi, Romulo [1, 2] ; Pasqua, Leonardo A. [2] ; Bueno, Salomao [2] ; Lima-Silva, Adriano Eduardo [3] ; Matsuda, Monique [4] ; Marquezini, Monica [1] ; Saldiva, Paulo H. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Expt Air Pollut, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport, Endurance Sports Res Grp, Sao Paulo - Brazil
[3] Univ Fed Pernambuco, Acad Ctr Vitoria, Sports Sci Res Grp, Vitoria De Santo Antao - Brazil
[4] Univ Sao Paulo, Fac Med, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PLoS One; v. 9, n. 9 SEP 4 2014.
Web of Science Citations: 4
Abstract

The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that COL5A1 rs12722 may influence the elasticity of tendons and the energetic cost of running. To date, there are no experimental data in the literature supporting the relationship between range of motion, running economy, and the COL5A1 rs12722 gene polymorphism. Therefore, the main purpose of the current study was to analyze the influence of the COL5A1rs12722 polymorphism on running economy and range of motion. One hundred and fifty (n = 150) physically active young men performed the following tests: a) a maximal incremental treadmill test, b) two constant-speed running tests (10 km.h(-1) and 12 km.h(-1)) to determine the running economy, and c) a sit-and-reach test to determine the range of motion. All of the subjects were genotyped for the COL5A1 rs12722 single-nucleotide polymorphism. The genotype frequencies were TT = 27.9%, CT = 55.8%, and CC = 16.3%. There were no significant differences between COL5A1 genotypes for running economy measured at 10 km.h(-1) (p = 0.232) and 12 km.h(-1) (p = 0.259). Similarly, there were no significant differences between COL5A1 genotypes for range of motion (p = 0.337). These findings suggest that the previous relationship reported between COL5A1 rs12722 genotypes and running endurance performance might not be mediated by the energetic cost of running. (AU)

FAPESP's process: 10/13913-6 - Running economy and muscle strength: a relationship with ACTN3 gene R577X polymorphism
Grantee:Leonardo Alves Pasqua
Support Opportunities: Scholarships in Brazil - Master