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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antileishmanial activity evaluation of adunchalcone, a new prenylated dihydrochalcone from Piper aduncum L.

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Dal Picolo, Camilla R. [1] ; Bezerra, Mariana P. [1] ; Gomes, Kaio S. [1] ; Passero, Luiz Felipe D. [2] ; Laurenti, Marcia D. [2] ; Martins, Euder Glendes A. [3] ; Sartorelli, Patricia [1] ; Lago, Joao Henrique G. [1]
Total Authors: 8
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Dept Patol, Lab Patol Molestias Infecciosas LIM50, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biociencias, Dept Bot, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Fitoterapia; v. 97, p. 28-33, SEP 2014.
Web of Science Citations: 20

Bioactivity-guided fractionation of EtOH extract from the leaves of Piper aduncum L. (Piperaceae) afforded a new dihydrochalcone, named adunchalcone. Its structure was elucidated on the basis of their spectroscopic data, primarily NMR and MS. Adunchalcone was evaluated against promastigote forms of Leishmania (L.) amazonensis, L. (V.) braziliensis, L. (V.) shawl, and L. (L.) chagasi and displayed 50% effective concentrations (EC50) of 11.03, 26.70, and 11.26 mu M, as well as selective indexes of 4.86, 2.01, 4.76 and 0.50, respectively. This compound was also tested against intracellular forms of L. (L.) amazonensis, displaying weak activity, in comparison to reference drug amphotericin B. However, despite reduced effect of adunchalcone against amastigotes of L. (L.) amazonensis, this work opens the perspective to use this particular molecule as a scaffold for the design of novel and selective drug candidates for neglected diseases, mainly leishmaniasis. (c) 2014 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/51739-0 - Sustainable use of biodiversity in Atlantic Forest remnants in São Paulo: evaluation, isolation and molecular characterization of bioactive secondary metabolites in plant species
Grantee:João Henrique Ghilardi Lago
Support type: BIOTA-FAPESP Program - Regular Research Grants