Matrix metalloproteinases and left ventricular function and structure in spinal cord injured subjects

Author(s):Show less -

Schreiber, Roberto ^[1] ; Paim, Layde R. ^[1] ; de Rossi, Guilherme ^[1] ; Matos-Souza, Jose R. ^[1] ; Costa e Silva, Anselmo de A. ^[2] ; Souza, Cristiane M. ^[1] ; Borges, Mariane ^[2] ; Azevedo, Eliza R. ^[3] ; Alonso, Karina C. ^[3] ; Gorla, Jose I. ^[2] ; Cliquet, Jr., Alberto ^{[4, 3]} ; Nadruz, Jr., Wilson ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Internal Med, BR-13081970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Phys Educ, BR-13081970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Dept Orthopaed, Sch Med Sci, BR-13081970 Campinas, SP - Brazil

^[4] Univ Sao Paulo, Dept Elect Engn, Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Clinica Chimica Acta; v. 437, p. 136-140, NOV 1 2014.
• Web of Science Citations: 3

Abstract

Subjects with spinal cord injury (SCI) exhibit impaired left ventricular (LV) diastolic function, which has been reported to be attenuated by regular physical activity. This study investigated the relationship between circulating matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) and echocardiographic parameters in SCI subjects and the role of physical activity in this regard. Forty-two men with SCI {[}19 sedentary (S-SCI) and 23 physically-active (PA-SCI)] were evaluated by clinical, anthropometric, laboratory, and echocardiographic analysis. Plasmatic pro-MMP-2, MMP-2, MMP-8, pro-MMP-9, MMP-9, TIMP-1 and TIMP-2 levels were determined by enzyme-linked immunosorbent assay and zymography. PA-SCI subjects presented lower pro-MMP-2 and pro-MMP-2/TIMP-2 levels and improved markers of LV diastolic function (lower E/Em and higher Em and E/A values) than S-SCI ones. Bivariate analysis showed that pro-MMP-2 correlated inversely with Em and directly with E/Em, while MMP-9 correlated directly with LV mass index and LV end-diastolic diameter in the whole sample. Following multiple regression analysis, pro-MMP-2, but not physical activity, remained associated with Em, while MMP-9 was associated with LV mass index in the whole sample. These findings suggest differing roles for MMPs in LV structure and function regulation and an interaction among pro-MMP-2, diastolic function and physical activity in SCI subjects. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 10/16252-0 - Mechanisms related to increased cardiovascular risk in spinal cord injury subjects
• Grantee: Wilson Nadruz Junior
• Support Opportunities: Regular Research Grants