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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nevus-Associated Melanomas: Clinicopathologic Features

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Shitara, Danielle [1] ; Nascimento, Mauricio M. [1] ; Puig, Susana [2, 3] ; Yamada, Sergio [1] ; Enokihara, Milvia M. S. S. [1, 4] ; Michalany, Nilceo [1, 4] ; Bagatin, Edileia [1]
Total Authors: 7
[1] Univ Fed Sao Paulo, Dept Dermatol, BR-04038001 Sao Paulo - Brazil
[2] Univ Barcelona, Dept Dermatol, Hosp Clin Barcelona, Melanoma Unit, IDIBAPS, Barcelona - Spain
[3] Inst Salud Carlos III, CIBER Enfermedades Raras, Barcelona - Spain
[4] Univ Fed Sao Paulo, Dept Pathol, BR-04038001 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: American Journal of Clinical Pathology; v. 142, n. 4, p. 485-491, OCT 2014.
Web of Science Citations: 14

Objectives: The clinical significance of nevus-associated melanoma compared with de novo melanomas remains controversial. It has been suggested that nevus-associated melanomas have a higher Breslow thickness and therefore worse prognosis. Over a 10-year period, this study evaluated the incidence of nevus-associated melanoma and its prognostic significance related to clinicopathologic features. Methods: Cross-sectional study from 1995 through 2004 in a dermatopathology referral center. With available data, we evaluated sex, primary location, histologic subtype, Breslow thickness, Clark level, presence of ulceration, associated lesion, and histologic subtype of the associated lesion. Results: Of 135,653 pathologic records from skin biopsy specimens over a 10-year period, 1,190 melanoma records were selected Nevus-associated melanomas corresponded to 390 (32.8%) melanomas, with thin melanomas having a nevus 1.52 times the association observed with thick melanomas (>1.01 mm; 95% confidence interval, 1.16-1.99; P <.001). Superficial spreading melanoma was the most frequent, while no lentigo maligna melanoma was associated with nevi. The median Breslow thickness of nevus-associated melanomas was lower than that of de novo melanomas. Conclusions: Nevus-associated melanomas, which represent one-third of the melanomas in southeast Brazil, are associated with intermittent sun exposure, superficial spreading melanomas, and lower Breslow thickness. This is one of the largest series describing nevus-associated melanomas in Latin America. (AU)

FAPESP's process: 12/15238-0 - Retrospective study for the analysis of mutations in melanomas and associated nevi, present within the same lesion, through paraffin DNA extraction
Grantee:Ediléia Bagatin
Support type: Regular Research Grants
FAPESP's process: 12/20683-2 - Proyecto de investigacion de doctorado en dermatologia
Grantee:Danielle Ioshimoto Shitara Do Nascimento
Support type: Scholarships abroad - Technical Training Program - Participation in Course