| Full text | |
| Author(s): |
Blanch, Graziela Torres
[1]
;
Freiria-Oliveira, Andre Henrique
[1]
;
Fina Speretta, Guilherme Fleury
[1]
;
Carrera, Eduardo J.
[2]
;
Li, Hongwei
[3]
;
Speth, Robert C.
[4, 5, 2]
;
Colombari, Eduardo
[1]
;
Sumners, Colin
[4, 5]
;
Colombari, Debora S. A.
[1]
Total Authors: 9
|
| Affiliation: | [1] Sao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Sao Paulo - Brazil
[2] Nova SE Univ, Coll Pharm, Dept Pharmaceut Sci, Ft Lauderdale, FL 33314 - USA
[3] Southern Med Univ, Sch Biotechnol, Guangzhou, Guangdong - Peoples R China
[4] Univ Florida, Coll Med, Dept Physiol & Funct Genom, Gainesville, FL - USA
[5] Univ Florida, Coll Med, McKnight Brain Inst, Gainesville, FL - USA
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Hypertension; v. 64, n. 4, p. 777+, OCT 2014. |
| Web of Science Citations: | 21 |
| Abstract | |
Angiotensin II increases and decreases arterial pressure by acting at angiotensin type 1 and type 2 receptors, respectively. Renovascular hypertensive rats exhibit a high level of activity of the peripheral and central renin-angiotensin system. Therefore, in the present study, we evaluated the effect of increasing the expression of angiotensin type 2 receptors in the solitary-vagal complex (nucleus of the solitary tract/dorsal motor nucleus of the vagus), a key brain stem region for cardiovascular regulation, on the development of renovascular hypertension. Holtzman normotensive rats were implanted with a silver clip around the left renal artery to induce 2-kidney 1-clip renovascular hypertension. Three weeks later, rats were microinjected in the solitary-vagal complex with either an adenoassociated virus to increase the expression of angiotensin type 2 receptors or with a control vector. We observed that increasing angiotensin type 2 receptor expression in the solitary-vagal complex attenuated the development of renovascular hypertension and also reversed the impairment of the baroreflex and the increase in the low-frequency component of systolic blood pressure observed in renovascular hypertensive rats. Furthermore, an observed decrease in mRNA levels of angiotensin-converting enzyme 2 in the solitary-vagal complex of renovascular hypertensive rats was restored to control levels after viral-mediated increases in angiotensin type 2 receptors at this site. Collectively, these data demonstrate specific and beneficial effects of angiotensin type 2 receptors via the brain of hypertensive rats and suggest that central angiotensin type 2 receptors may be a potential target for therapeutics in renovascular hypertension. (AU) | |
| FAPESP's process: | 11/50770-1 - Neural mechanisms involved of hydroelectrolytic balance and cardiorespiratory control |
| Grantee: | José Vanderlei Menani |
| Support Opportunities: | Research Projects - Thematic Grants |