IL28B Gene Polymorphism SNP rs8099917 Genotype GG Is Associated with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in HTLV-1 Carriers

Author(s):Show less -

Assone, Tatiane ^{[1, 2]} ; de Souza, Fernando Vieira ^[3] ; Gaester, Karen Oliveira ^{[1, 2]} ; Marcondes Fonseca, Luiz Augusto ^[4] ; Luiz, Olinda do Carmo ^[4] ; Malta, Fernanda ^[1] ; Rebello Pinho, Joao Renato ^[1] ; Goncalves, Fernanda de Toledo ^[5] ; da Silva Duarte, Alberto Jose ^[2] ; Penalva de Oliveira, Augusto Cesar ^[3] ; Casseb, Jorge ^{[1, 2]}

Affiliation

^[1] Inst Med Trop Sao Paulo, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept Dermatol, Lab Dermatol & Imunodeficiencias, Sao Paulo - Brazil

^[3] Inst Doencas Infecciosas Emilio Ribas IIER Sao Pa, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med, Dept Med Prevent, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Fac Med, Dept Med Legal Et Med Social & Trabalho, Lab Imunohematol & Hematol Forense LIM40, Sao Paulo - Brazil

• Document type: Journal article
• Source: PLoS Neglected Tropical Diseases; v. 8, n. 9 SEP 2014.
• Web of Science Citations: 15

Abstract

Background: The polymorphisms of IL28B have been described as important in the pathogenesis of infections caused by some viruses. The aim of this research was to evaluate whether IL28B gene polymorphisms (SNP rs8099917 and SNP rs12979860) are associated with HAM/TSP. Methods: The study included 229 subjects, classified according to their neurological status in two groups: Group I (136 asymptomatic HTLV-1 carriers) and Group II (93 HAM/TSP patients). The proviral loads were quantified, and the rs8099917 and rs12979860 SNPs in the region of IL28B-gene were analyzed by StepOnePlus Real-time PCR System. Results: A multivariate model analysis, including gender, age, and HTLV-1 DNA proviral load, showed that IL28B polymorphisms were independently associated with HAM/TSP outcome in rs12979860 genotype CT (OR = 2.03; IC95% = 0.96-4.27) and in rs8099917 genotype GG (OR = 7.61; IC95% = 1.82-31.72). Conclusion: Subjects with SNP rs8099917 genotype GG and rs12979618 genotype CT may present a distinct immune response against HTLV-1 infection. So, it seems reasonable to suggest that a search for IL28B polymorphisms should be performed for all HTLV-1-infected subjects in order to monitor their risk for disease development; however, since this is the first description of such finding in the literature, we should first replicate this study with more HTLV-1-infected persons to strengthen the evidence already provided by our results. (AU)

• FAPESP's process: 12/23397-0 - Determination of IL28B polymorphism profile in patients co-infected with Chronic Hepatitis C (HCV) virus and human T-lymphotropic type 1 (HTLV-1)
• Grantee: Jorge Simao do Rosario Casseb
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/07076-4 - Prevalence and in vitro specific immune response to human papillomavirus (HPV) in HIV-1-infected men in the São Paulo City, Brazil.
• Grantee: Jorge Simao do Rosario Casseb
• Support Opportunities: Regular Research Grants