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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nerve Regeneration: Is There an Alternative to Nervous Graft?

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Author(s):
Sabongi, Rodrigo Guerra [1] ; Lucas Martins De Rizzo, Luiz Augusto [2] ; Fernandes, Marcela [3] ; Valente, Sandra Gomes [3] ; Gomes dos Santos, Joao Baptista [1] ; Faloppa, Flavio [1] ; Leite, Vilnei Mattioli [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Orthoped & Traumatol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Dept Orthoped & Traumatol, Div Hand Surg, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF RECONSTRUCTIVE MICROSURGERY; v. 30, n. 9, p. 607-616, NOV 2014.
Web of Science Citations: 10
Abstract

Background In nerve injury with nervous gap, no restitution method was found better than the autograft, however, it has the disadvantage of damaging a normal nerve to be used as a graft. Platelet-rich plasma (PRP) is a possible filler material for vein grafts used as conduits for nerve regeneration, preventing its collapse, and providing growth factors and osteoconductive proteins. Methods Isogenic rats were randomly divided into three groups. They received nerve autografts (GRF), PRP-containing vein grafts or a sham operation. Outcomes were evaluated by the sciatic functional index (SFI), morphometric, and morphologic analyses of the nerve distal to the lesion, and the number of spinal cord motoneurons positive for retrograde Fluoro-Gold (Santa Cruz Biotechnology, Inc., Dallas, TX) tracer. Results The PRP and GRF groups had lower SFI values than the control animals throughout the postoperative period. The SFI was significantly higher in the PRP group than the GRF group at 90 days postoperatively (p = 0.011). Fiber diameter and number of motoneurons were significantly decreased in both the PRP and GRF groups, as compared with the control. Conclusion PRP within a vein conduit may be an effective alternative or adjuvant to GRF, the current preferred treatment for nerve injury with a nerve gap, and further investigations are required to fully define the role of PRP in nerve regeneration. (AU)

FAPESP's process: 10/52624-0 - Evaluation of ischiatic nerve regeneration, in SHR rats, using autologous vein graft filled with platelet-rich plasma
Grantee:Joao Baptista Gomes dos Santos
Support Opportunities: Regular Research Grants