Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier

Author(s)

Orsi, Fernanda Andrade ^[1] ; Angerami, Rodrigo Nogueira ^[2] ; Mazetto, Bruna Moraes ^[1] ; Quaino, Susan Kelly Picoli ^[1] ; de Paula, Erich Vinicius ^[3] ; Annichino-Bizzachi, Joyce Maria ^[1]

Affiliation

^[1] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Lab Hemostasis, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Epidemiol Surveillance Ctr, Hosp Clin, BR-13083970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Fac Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES; v. 8, n. 6, p. 799-803, JUN 2014.
• Web of Science Citations: 0

Abstract

Bleeding complications in dengue may occur irrespective of the presence of plasma leakage. We compared plasma levels of modulators of the endothelial barrier among three dengue groups: bleedings without plasma leakage, dengue hemorrhagic fever, and non-complicated dengue. The aim was to evaluate whether the presence of subtle alterations in microvascular permeability could be detected in bleeding patients. Plasma levels of VEGF-A and its soluble receptors were not associated with the occurrence of bleeding in patients without plasma leakage. These results provide additional rationale for considering bleeding as a complication independent of endothelial barrier breakdown, as proposed by the 2009 WHO classification. (AU)

• FAPESP's process: 08/11518-2 - Evaluation of hemostasis abnormalities related to hemorrhagic fever diseases
• Grantee: Joyce Maria Annichino-Bizzacchi
• Support Opportunities: Regular Research Grants