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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A comparative in vivo ultrasonometric evaluation of normal and delayed fracture healing in sheep tibiae

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Author(s):
Barbieri, Giuliano [1] ; Barbieri, Claudio Henrique [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Biomech Med & Rehabil Locomotor Apparat, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Clinics; v. 69, n. 9, p. 634-640, 2014.
Web of Science Citations: 4
Abstract

OBJECTIVE: To compare normal and delayed bone healing by measuring ultrasound conduction velocity across the bone callus. METHODS: A model of transverse linear and 5 mm resection osteotomies of sheep tibiae was used. Fourteen sheep were operated on and were divided into two groups of seven according to osteotomy type. The procedure was performed on the right tibiae and the intact left tibiae were used as controls. The transverse and axial ultrasound velocities were measured at 30-day intervals for 90 days, after which the animals were killed and both the right and left tibiae were resected for in vitro biomechanical analysis. RESULTS: Both the transverse and axial ultrasound velocities progressively increased, but the increase was smaller for the delayed union that resulted from the resection osteotomy. The mechanical resistance was higher for the normally healed tibiae that resulted from a linear osteotomy; this result closely correlated with the ultrasound velocity results. Significant differences were found for the comparisons between the intact and operated tibiae in both groups and between the groups for both the transverse and axial ultrasound velocities, but the differences were greater for the latter. CONCLUSION: We conclude that in vivo transverse and axial ultrasound velocities provide highly precise information about the healing state of both linear and resection diaphyseal osteotomies, but the axial ultrasound velocity most likely has greater discriminatory power. This method has the potential for clinical application in humans. (AU)

FAPESP's process: 07/56422-0 - Ultrasonometric evaluation of bone healing and cortical bone density
Grantee:Claudio Henrique Barbieri
Support Opportunities: Research Projects - Thematic Grants