Transplacental Total IgG Transfer in Twin Pregnancies

Author(s)

Stach, Sonia C. L. ^[1] ; Brizot, Maria de L. ^[1] ; Liao, Adolfo W. ^[1] ; Francisco, Rossana P. V. ^[1] ; Palmeira, Patricia ^[2] ; Carneiro-Sampaio, Magda ^[2] ; Zugaib, Marcelo ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Med, Dept Obstet & Gynecol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Pediat, Sao Paulo - Brazil

• Document type: Journal article
• Source: American Journal of Reproductive Immunology; v. 72, n. 6, p. 555-560, DEC 2014.
• Web of Science Citations: 3

Abstract

ProblemIn twin pregnancies, factors that influence total umbilical cord IgG concentration and IgG transfer ratio are not well known. MethodBlood samples were prospectively collected from 57 twin pregnancies. Stepwise multivariate regression analysis was used to evaluate the association between total IgG levels in the umbilical cord blood and IgG transfer ratio according to serum IgG concentration, pregnancy chorionicity, the presence of abnormal umbilical artery pulsatility index, intrauterine growth restriction, gestational age at delivery (GAD), birthweight, and placental weight. ResultsUmbilical cord IgG concentration showed a positive correlation with serum IgG concentration and GAD; levels were significantly lower in monochorionic compared with dichorionic pregnancies. IgG transfer ratio also increased with GAD but was inversely correlated with serum IgG concentration levels. ConclusionIn twin pregnancies, besides serum IgG concentration and GAD, chorionicity also influences umbilical cord IgG concentration. Monochorionic twins have lower IgG cord concentration than dichorionic twins. (AU)

• FAPESP's process: 11/13587-4 - Placental transfer of antibodies in multiple pregnancies
• Grantee: Maria de Lourdes Brizot
• Support Opportunities: Regular Research Grants