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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The intracarotid etomidate Wada test: A 54-patient series

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Author(s):
Passarelli, Valmir [1] ; Pinto, Lecio F. [1] ; Jorge, Carmen L. [1] ; Puglia, Paulo [1] ; Adda, Carla C. [1] ; Wen, Hung-Tzu [1] ; Castro, Luiz H. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Hosp Clin, Dept Neurol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Epilepsy & Behavior; v. 39, p. 73-77, OCT 2014.
Web of Science Citations: 3
Abstract

Hemispheric language dominance and isolated hemispheric memory function evaluation can be undertaken with the intracarotid injection of a general anesthetic agent (Wada test). Amobarbital has been traditionally used as the anesthetic agent, but legal and commercial constraints limit its use. We evaluated the use of etomidate as an alternative agent for the Wada test in a series of 54 consecutive adult patients with mesial temporal sclerosis undergoing presurgical evaluation for epilepsy surgery. Language lateralization and hemispheric memory function evaluation were successfully achieved in all cases. Side effects (somnolence, tremor, and dystonia) were infrequent, minor, and transient and did not require interruption of the procedure. Etomidate appears to be a safe and effective alternative agent to amobarbital in the Wada test. Similarly to the amobarbital Wada test, the ability of the etomidate Wada test to predict postoperative memory decline remains unclear. (C) 2014 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 05/56464-9 - Neuroscience Imaging Center at University of São Paulo Medical School
Grantee:Giovanni Guido Cerri
Support Opportunities: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants