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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Body composition and weight gain in new users of the three-monthly injectable contraceptive, depot-medroxyprogesterone acetate, after 12 months of follow-up

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Author(s):
Silva dos Santos, Priscilla de Nazare [1] ; Modesto, Waleska Oliveira [1] ; Dal'Ava, Nathalia [1] ; Bahamondes, Maria Valeria [1] ; Pavin, Elizabeth Joao [2] ; Fernandes, Arlete [1]
Total Authors: 6
Affiliation:
[1] Univ Campinas UNICAMP, Sch Med Sci, Dept Obstet & Gynaecol, Human Reprod Unit, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Med, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE; v. 19, n. 6, p. 432-438, DEC 2014.
Web of Science Citations: 6
Abstract

Objectives To evaluate weight gain and body composition (BC) in new users of depot-medroxyprogesterone acetate (DMPA) as a contraceptive. Methods This cohort study followed up 20 DMPA users and 20 copper intrauterine device (TCu380A IUD) users, paired for age (+/- 1 year) and body mass index (BMI +/- 1 kg/m 2), during 12-months. Healthy, non-obese women aged 18 to 40 years, unaffected by conditions that could influence their body weight, were enrolled. Socio-demographic variables, habits, weight, BMI, BC using dual-energy X-ray absorptiometry, circumferences, skinfold thickness, body fat percentage and waist-to-hip ratio were evaluated. All participants were encouraged to adopt healthy habits. Results At baseline, median age was 29 and 30.5 years, and mean BMI was 24.8 and 24.5 kg/m 2 in the DMPA and IUD groups, respectively. At 12 months, an increase was observed in waist and hip circumference in the DMPA users and 8/20 of them had a weight gain >= 5% (mean 4.6 kg) with accumulation of fat centrally. Conclusions There were no differences in weight gain or in BC measurements between the groups; nevertheless 40% of women in the DMPA group had larger weight gain and accumulation of fat centrally. The duration of follow-up may have been insuffi cient to detect differences between the groups. (AU)

FAPESP's process: 09/53293-0 - Prospective study for evaluation of the insulin resistance, lipid metabolism and sub clinical cardiovascular disease in women who initiate the depot-medroxyprogesterone acetate (DMP A) contraceptive method with in follow-up for two years. (Project of scientific research)
Grantee:Luis Guillermo Bahamondes
Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)