| Full text | |
| Author(s): |
De Aro, Andrea Aparecida
[1]
;
Marretto Esquisatto, Marcelo Augusto
[2]
;
Nishan, Umar
[1, 3]
;
Perez, Mylena Oliveira
[1]
;
Ferreira Rodrigues, Rodney Alexandre
[4]
;
Foglio, Mary Ann
[4]
;
De Carvalho, Joao Ernesto
[4]
;
Gomes, Laurecir
[1]
;
Vidal, Benedicto De Campos
[1]
;
Pimentel, Edson Rosa
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, UNICAMP, BR-13083970 Campinas, SP - Brazil
[2] Herminio Ometto Univ Ctr FHO UNIARARAS, Biomed Sci Grad Program, Sao Paulo - Brazil
[3] Bahauddin Zakariya Univ, Dept Biochem, Multan - Pakistan
[4] Univ Estadual Campinas, Chem Biol & Agr Pluridisciplinary Res Ctr CPQBA, UNICAMP, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | MICROSCOPY RESEARCH AND TECHNIQUE; v. 77, n. 12, p. 964-973, DEC 2014. |
| Web of Science Citations: | 3 |
| Abstract | |
Although several treatments for tendon lesions have been proposed, successful tendon repair remains a great challenge for orthopedics, especially considering the high incidence of re-rupture of injured tendons. Our aim was to evaluate the pharmacological potential of Aloe vera on the content and arrangement of glycosaminoglycans (GAGs) during tendon healing, which was based on the effectiveness of A. vera on collagen organization previously observed by our group. In rats, a partial calcaneal tendon transection was performed with subsequent topical A. vera application at the injury site. The tendons were treated with A. vera ointment for 7 days and excised on the 7(th), 14(th), or 21(st) day post-surgery. Control rats received ointment without A. vera. A higher content of GAGs and a lower amount of dermatan sulfate were detected in the A. vera-treated group on the 14(th) day compared with the control. Also at 14 days post-surgery, a lower dichroic ratio in toluidine blue stained sections was observed in A. vera-treated tendons compared with the control. No differences were observed in the chondroitin-6-sulfate and TGF-1 levels between the groups, and higher amount of non-collagenous proteins was detected in the A. vera-treated group on the 21(st) day, compared with the control group. No differences were observed in the number of fibroblasts, inflammatory cells and blood vessels between the groups. The application of A. vera during tendon healing modified the arrangement of GAGs and increased the content of GAGs and non-collagenous proteins. Microsc. Res. Tech. 77:964-973, 2014. (c) 2014 Wiley Periodicals, Inc. (AU) | |
| FAPESP's process: | 08/05912-0 - Effect of the Aloe vera and Arrabidaea chica extracts on the healing of rat calcaneal tendon after partial transection |
| Grantee: | Andréa Aparecida de Aro |
| Support Opportunities: | Scholarships in Brazil - Doctorate |