| Full text | |
| Author(s): |
Gomes Cunha, Debora Maria
[1]
;
Koike, Marcia Kiyomi
[1]
;
Frediani Barbeiro, Denise
[1]
;
Barbeiro, Hermes Vieira
[1]
;
Hamasaki, Mike Yoshio
[1]
;
Coelho Neto, Guilherme Tude
[1]
;
Cesar Machado, Marcel Cerqueira
[1]
;
da Silva, Fabiano Pinheiro
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Dept Emergency Med, BR-01246000 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Experimental Gerontology; v. 60, p. 215-219, DEC 2014. |
| Web of Science Citations: | 12 |
| Abstract | |
Acute pancreatitis is a life-threatening situation, frequently associated with uncontrolled local and systemic inflammation, and aging is associated with a worst prognosis. Antimicrobial peptides are ancient molecules that belong to innate immunity, produced by epithelial and immune cells, and are able to trigger a myriad of effector responses. We have hypothesized that antimicrobial peptides could play an important role during serious pancreatic injury. To investigate our hypothesis, alpha-defensin-5, alpha-defensin-7 and CRAMP gene expression levels were measured in the intestinal tissue of old and young rats submitted to chemical pancreatic damage. We found significantly higher levels of alpha-defensin-5 and alpha-defensin-7, but not CRAMP, in the samples from old mice. This increase was not associated with a worse systemic inflammatory response. We conclude that alpha-defensins may have a pivotal role during acute pancreatitis and that the elderly develops a more severe local, but not systemic inflammatory process. (C) 2014 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 09/17731-2 - Markers of infection in critically ill patients |
| Grantee: | Fabiano Pinheiro da Silva |
| Support Opportunities: | Research Grants - Young Investigators Grants |