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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Feasibility and reproducibility of diffusion-weighted magnetic resonance imaging of the fetal brain in twin-twin transfusion syndrome

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Author(s):
Neto, Orlando Gomes [1] ; Marins, Marcos [2] ; Botelho, Rafael D. [1] ; Nivoloni, Rafaela C. [2] ; Saura, Glauco E. [2] ; Arias, Amabile Vessoni [3] ; Barini, Ricardo [1] ; Peralta, Cleisson F. A. [1]
Total Authors: 8
Affiliation:
[1] State Univ Campinas UNICAMP, Prof Jose Aristodemo Pinotti Hosp, Dept Obstet & Gynecol, Ctr Integral Assistance Womens Hlth, Campinas, SP - Brazil
[2] Vera Cruz Hosp, CRC, Campinas, SP - Brazil
[3] State Univ Campinas UNICAMP, Dept Neurol, Clin Hosp, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PRENATAL DIAGNOSIS; v. 34, n. 12, p. 1182-1188, DEC 2014.
Web of Science Citations: 2
Abstract

ObjectiveThe aim of this study is to test the feasibility and reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) evaluations of the fetal brains in cases of twin-twin transfusion syndrome (TTTS). MethodFrom May 2011 to June 2012, 24 patients with severe TTTS underwent MRI scans for evaluation of the fetal brains. Datasets were analyzed offline on axial DW images and apparent diffusion coefficient (ADC) maps by two radiologists. The subjective evaluation was described as the absence or presence of water diffusion restriction. The objective evaluation was performed by the placement of 20-mm(2) circular regions of interest on the DW image and ADC maps. Subjective interobserver agreement was assessed by the kappa correlation coefficient. Objective intraobserver and interobserver agreements were assessed by proportionate Bland-Altman tests. ResultsSeventy-four DW-MRI scans were performed. Sixty of them (81.1%) were considered to be of good quality. Agreement between the radiologists was 100% for the absence or presence of diffusion restriction of water. For both intraobserver and interobserver agreement of ADC measurements, proportionate Bland-Altman tests showed average percentage differences of less than 1.5% and 95% CI of less than 18% for all sites evaluated. ConclusionOur data demonstrate that DW-MRI evaluation of the fetal brain in TTTS is feasible and reproducible. (c) 2014 John Wiley \& Sons, Ltd. (AU)

FAPESP's process: 11/18469-0 - Evaluation of the fetal and neonatal brains in cases of severe twin-twin transfusion syndrome treated with laser ablation of placental vessels
Grantee:Cleisson Fabio Andrioli Peralta
Support Opportunities: Regular Research Grants