Bone marrow cytological evaluation in dogs with chronic kidney disease

Author(s)

Borin-Crivellenti, S. ^[1] ; Crivellenti, L. Z. ^[1] ; Carvalho, M. B. ^[1] ; Santana, A. E. ^[1]

Affiliation

^[1] Univ Estadual Paulista, UNESP, Jaboticabal, SP - Brazil

• Document type: Journal article
• Source: Arquivo Brasileiro de Medicina Veterinária e Zootecnia; v. 66, n. 6, p. 1751-1756, DEC 2014.
• Web of Science Citations: 0

Abstract

Since anemia is indicated as an important compromising factor for the quality of life of dogs with chronic kidney disease (CKD), bone marrow cytological analysis may provide more information on the hematological profile these dogs and, therefore, allow clinicians to not only choose the most adequate treatment but also monitor the response to therapy. The aim of this study was to investigate the feasibility with sternal bone marrow puncture in chronic kidney disease (CKD) using only local anesthesia and check if the cytological analysis is helpful to determine the hematological status. We found that erythroid hypoplasia occurred only in terminal CKD patients, and that the bone marrows of dogs with CKD stages 2 and 3 were quantitatively similar to those of elderly dogs. All dogs tolerated the bone marrow puncture using only local anesthesia with lidocaine and bone marrow cytological evaluation may be a useful tool for hematopoietic evaluation of anemic dogs with CKD. (AU)

• FAPESP's process: 09/52230-4 - Imunofenotipagem de células CD45+ no sangue e na medula óssea de cães com anemia hipoplástica decorrente da insuficiência renal crônica
• Grantee: Áureo Evangelista Santana
• Support Opportunities: Regular Research Grants
• FAPESP's process: 08/56616-1 - Estudo prospectivo de hipoplasia sanguinea e quantificacao imunofenotipica de celulas cd 45+ no sangue e na medula ossea de caes atendidos junto ao hospital-escola da fcav/unesp.
• Grantee: Sofia Borin Crivellenti
• Support Opportunities: Scholarships in Brazil - Master