Weight variation in users of depot-medroxyprogesterone acetate, the levonorgestrel-releasing intrauterine system and a copper intrauterine device for up to ten years of use

Author(s)

Modesto, Waleska ^[1] ; Silva dos Santos, Priscila de Nazare ^[1] ; Correia, Vinicius Machado ^[1] ; Borges, Luiza ^[1] ; Bahamondes, Luis ^[1]

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Natl Inst Hormones & Womens Hlth, Campinas, SP - Brazil

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE; v. 20, n. 1, p. 57-63, FEB 2015.
• Web of Science Citations: 11

Abstract

Background and objective Data on record regarding weight variation in depot-medroxyprogesterone acetate (DMPA) and levonorgestrel-releasing intrauterine system (LNG-IUS) users are controversial. To date, no studies have yet evaluated weight variation in DMPA and LNG-IUS users in up to ten years of use compared to non-hormonal contraceptive users. Materials and methods A retrospective study analysed weight variations in 2138 women using uninterruptedly DMPA (150 mg intramuscularly, three-monthly; n = 714), the LNGIUS (n = 701) or a copper-intrauterine device (Cu-IUD; n = 723). Results At the end of the first year of use, there was a mean weight increase of 1.3 kg, 0.7 kg and 0.2 kg among the DMPA-, LNG-IUS-and Cu-IUD users, respectively, compared to weight at baseline (p < 0.0001). After ten years of use, the mean weight had risen by 6.6 kg, 4.0 and 4.9 kg among the DMPA-, LNG-IUS-and Cu-IUD users, respectively. DMPA-users had gained more weight than LNG-IUS-(p = 0.0197) and than Cu-IUD users (p = 0.0294), with the latter two groups not differing significantly from each other in this respect (p = 0.5532). Conclusion Users of hormonal and non-hormonal contraceptive methods gained a signifi cant amount of weight over the years. DMPA users gained more weight over the treatment period of up to ten years than women fitted with either a LNG-IUS or a Cu-IUD. (AU)

• FAPESP's process: 11/01554-4 - Body composition and bone mineral density in users of depot medroxyprogesterone acetate compared to CIU Tcu380A Intrauterine Device
• Grantee: Waleska Oliveira Modesto
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/03590-3 - Effectiveness and duration of use of long term contraceptives
• Grantee: Vinícius Machado Correia
• Support Opportunities: Scholarships in Brazil - Scientific Initiation