| Full text | |
| Author(s): |
de Oliveira, Cristiane Beatriz
[1]
;
Vasconcellos, Cidia
[1]
;
Sakai-Valente, Neusa Y.
[2]
;
Sotto, Mirian Nacagami
[1]
;
Luiz, Fernanda Guedes
[3]
;
Belda Junior, Walter
[1]
;
Teixeira de Sousa, Maria da Gloria
[2]
;
Benard, Gil
[2]
;
Criado, Paulo Ricardo
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Dept Dermatol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Div Clin Dermatol, Lab Med Invest Unit 53, Sao Paulo - Brazil
[3] Inst Pasteur Sao Paulo, Lab Diagnost Raiva, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Revista do Instituto de Medicina Tropical de São Paulo; v. 57, n. 1, p. 57-61, JAN-FEB 2015. |
| Web of Science Citations: | 9 |
| Abstract | |
There are few studies on the role of innate immune response in dermatophytosis. An investigation was conducted to define the involvement of Toll-Like Receptors (TLRs) 2 and 4 in localized (LD) and disseminated (DD) dermatophytosis due to T. rubrum. Fifteen newly diagnosed patients, eight patients with LD and seven with DD, defined by involvement of at least three body segments were used in this study. Controls comprised twenty skin samples from healthy individuals undergoing plastic surgery. TLR2 and TLR4 were quantified in skin lesions by immunohistochemistry. A reduced expression of TLR4 in the lower and upper epidermis of both LD and DD patients was found compared to controls; TLR2 expression was preserved in the upper and lower epidermis of all three groups. As TLR4 signaling induces the production of inflammatory cytokines and neutrophils recruitment, its reduced expression likely contributed to the lack of resolution of the infection and the consequent chronic nature of the dermatophytosis. As TLR2 expression acts to limit the inflammatory process and preserves the epidermal structure, its preserved expression may also contribute to the persistent infection and limited inflammation that are characteristic of dermatophytic infections. (AU) | |
| FAPESP's process: | 10/19369-6 - Characterization of the innate and adaptive immune responses during the infection with Trichophyton rubrum |
| Grantee: | Gil Benard |
| Support Opportunities: | Regular Research Grants |