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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Physiological and analgesic effects of continuous-rate infusion of morphine, butorphanol, tramadol or methadone in horses with lipopolysaccharide (LPS)-induced carpal synovitis

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Author(s):
Carregaro, Adriano B. [1] ; Freitas, Gabrielle C. [2] ; Ribeiro, Martina H. [1] ; Xavier, Nathalia V. [1] ; Doria, Renata G. S. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Vet Med, BR-13635900 Pirassununga Zip, SP - Brazil
[2] Fed Univ South Border, Coll Vet Med, Realeza, PR - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BMC Veterinary Research; v. 10, DEC 21 2014.
Web of Science Citations: 6
Abstract

Background: Continuous-rate infusion (CRI) of drugs results in more stable plasma drug concentrations than administration of intermittent boluses, thus providing greater stability of physiological parameters. The aim of this study was to evaluate the physiologic and analgesic effects of the administration of morphine, butorphanol, tramadol or methadone by CRI in horses with induced synovitis of the radiocarpal joint. Results: Increased values of cardiorespiratory parameters and body temperature were observed in all groups after initiation of opioid administration, and these increases were sustained throughout the CRI period. Morphine, butorphanol and methadone each caused a reduction in gut sounds, and this effect was greatest in animals that received morphine. Administration of morphine or methadone reduced the degree of lameness after the end of intravenous infusion. Administration of tramadol did not alter the degree of lameness in the animals. Conclusions: CRI of morphine or methadone, but not butorphanol or tramadol, provided analgesia in horses with carpal synovitis. All of these opioids increased cardiovascular and respiratory parameters and reduced gut sounds during CRI. (AU)

FAPESP's process: 12/06296-6 - Analgesia by continuous intravenous opioid infusion in horses with lipopolysaccharide (LPS) induced carpal Synovitis
Grantee:Adriano Bonfim Carregaro
Support Opportunities: Regular Research Grants