Epilepsy-induced electrocardiographic alterations following cardiac ischemia and reperfusion in rats

Author(s):Show less -

Tavares, J. G. P. ^{[1, 2, 3]} ; Vasques, E. R. ^[4] ; Arida, R. M. ^[5] ; Cavalheiro, E. A. ^[6] ; Cabral, F. R. ^[7] ; Torres, L. B. ^[7] ; Menezes-Rodrigues, F. S. ^[1] ; Jurkiewicz, A. ^[1] ; Caricati-Neto, A. ^[1] ; Godoy, C. M. G. ^[8] ; Gomes da Silva, S. ^{[7, 9]}

Affiliation

^[1] Univ Fed Sao Paulo, Dept Farmacol, Sao Paulo, SP - Brazil

^[2] Univ Iguacu, Itaperuna, RJ - Brazil

^[3] Fac Minas, Muriae, MG - Brazil

^[4] Univ Sao Paulo, Fac Med, Dept Gastroenterol, LIM 37, Sao Paulo, SP - Brazil

^[5] Univ Fed Sao Paulo, Dept Fisiol, Sao Paulo, SP - Brazil

^[6] Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP - Brazil

^[7] Hosp Israelita Albert Einstein, Inst Cerebro, Sao Paulo, SP - Brazil

^[8] Univ Fed Sao Paulo, Dept Ciencia & Tecnol, Sao Jose Dos Campos, SP - Brazil

^[9] Univ Mogi das Cruzes, Programa Integrado Engn Biomed, Nucleo Pesquisas Tecnol, Mogi Das Cruzes, SP - Brazil

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 48, n. 2, p. 140-145, FEB 2015.
• Web of Science Citations: 5

Abstract

The present study evaluated electrocardiographic alterations in rats with epilepsy submitted to an acute myocardial infarction (AMI) model induced by cardiac ischemia and reperfusion. Rats were randomly divided into two groups: control (n=12) and epilepsy (n=14). It was found that rats with epilepsy presented a significant reduction in atrioventricular block incidence following the ischemia and reperfusion procedure. In addition, significant alterations were observed in electrocardiogram intervals during the stabilization, ischemia, and reperfusion periods of rats with epilepsy compared to control rats. It was noted that rats with epilepsy presented a significant increase in the QRS interval during the stabilization period in relation to control rats (P<0.01). During the ischemia period, there was an increase in the QRS interval (P<0.05) and a reduction in the P wave and QT intervals (P<0.05 for both) in rats with epilepsy compared to control rats. During the reperfusion period, a significant reduction in the QT interval (P<0.01) was verified in the epilepsy group in relation to the control group. Our results indicate that rats submitted to an epilepsy model induced by pilocarpine presented electrical conductivity alterations of cardiac tissue, mainly during an AMI episode. (AU)

• FAPESP's process: 09/06953-4 - Brain plasticity induced by physical exercise
• Grantee: Ricardo Mario Arida
• Support Opportunities: Research Projects - Thematic Grants