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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Behavioural profile of Wistar rats with unilateral striatal lesion by quinolinic acid (animal model of Huntington disease) post-injection of apomorphine and exposure to static magnetic field

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Author(s):
Giorgetto, Carolina [1] ; Mazzei Silva, Elaine Cristina [1] ; Kitabatake, Takae Tamy [1] ; Bertolino, Guilherme [1] ; de Araujo, Joao Eduardo [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Lab Neuropsychobiol & Motor Behav, Dept Biomech Med & Rehabil Locomotor Syst, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Experimental Brain Research; v. 233, n. 5, p. 1455-1462, MAY 2015.
Web of Science Citations: 2
Abstract

We analysed the motor behaviour of Wistar rats after 7 days lesion in the left striatum, injected with apomorphine (APO) and stimulated by a continuous magnetic field of 3,200 Gauss. For the behaviour assessment, we utilised the activity cage test and the rotarod test. Sixty-eight male Wistar rats were divided into six groups: control, sham, sham magnetic, lesion, and stimulated South and North Poles. After the experiments, coronal sections of the striatum were taken and stained with Nissl for analysis of the lesion. In the activity cage test for distance (F = 3.19), time of activity (F = 5.46) and crossings (F = 3.31) in all groups, except for the North Pole-stimulated group, we observed a significant increase in these behaviours when compared to the control group. Considering the number of counterclockwise turns, we observed a significant increase in the lesion in the South and North Pole stimulation groups compared with the control group. Highlighting the minor number of counterclockwise turns observed in the North Pole-stimulated group in relation to the South Pole-stimulated and Lesion groups (F = 16.01). The rotarod test revealed a decrease in the time spent in this apparatus for the Lesion group when compared to all other groups (F = 5.46). The morphometric analysis showed a reduction in the number of neurons in the Lesion group in relation to all other groups (F = 5.13). Thus, the results suggest that the static magnetic field north and south promoted a distinct behavioural profile and morphological preservation after 7 days of lesion with quinolinic acid associated with APO. (AU)

FAPESP's process: 07/04560-0 - Behavioral effects and neuronial apoptotic alterations elicited for the continuous magnetic field in different areas of the central nervous system after experimentally induced lesions
Grantee:João Eduardo de Araujo
Support Opportunities: Research Grants - Young Investigators Grants