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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gonadal hormones modulate the responsiveness to local beta-blocker-induced antinociception in the temporomandibular joint of male and female rats

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Author(s):
Favaro-Moreira, N. C. [1] ; Okoti, L. W. [1] ; Furini, R. [1] ; Tambeli, C. H. [2]
Total Authors: 4
Affiliation:
[1] State Univ Campinas UNICAMP, Piracicaba Dent Sch, Lab Orofacial Pain, Dept Physiol Sci, Piracicaba - Brazil
[2] State Univ Campinas UNICAMP, Inst Biol, Dept Funct & Struct Biol, Piracicaba - Brazil
Total Affiliations: 2
Document type: Journal article
Source: EUROPEAN JOURNAL OF PAIN; v. 19, n. 6, p. 772-780, JUL 2015.
Web of Science Citations: 2
Abstract

BackgroundWe have previously demonstrated that blockade of -adrenoreceptors (-AR) located in the temporomandibular joint (TMJ) of rats suppresses formalin-induced TMJ nociceptive behaviour in both male and female rats, but female rats are more responsive. In this study, we investigated whether gonadal hormones modulate the responsiveness to local -blocker-induced antinociception in the TMJ of rats. MethodsCo-administration of each of the selective (1) (atenolol), (2) (ICI 118.551) and (3) (SR59230A)-AR antagonists with equi-nociceptive concentrations of formalin in the TMJ of intact, gonadectomized and hormone-treated gonadectomized male and female rats. ResultsAtenolol, ICI 118.551 and SR59230A significantly reduced formalin-induced TMJ nociception in a dose response fashion in all groups tested. However, a lower dose of each -AR antagonist was sufficient to significantly reduce nociceptive responses in gonadectomized but not in intact and testosterone-treated gonadectomized male rats. In the female groups, a lower dose of (1)-AR antagonist was sufficient to significantly reduce nociceptive responses in gonadectomized but not in intact or gonadectomized rats treated with progesterone or a high dose of oestradiol; a lower dose of (2)-AR antagonist was sufficient to significantly reduce nociceptive responses in gonadectomized but not in intact and gonadectomized rats treated with low or high dose of oestradiol. ConclusionGonadal hormones may reduce the responsiveness to local -blocker-induced antinociception in the TMJ of male and female rats. However, their effect depends upon their plasma level, the subtype of -AR and the dose of -blockers used. (AU)

FAPESP's process: 09/16991-0 - Effect of nadolol on temporomandibular pain.
Grantee:Nádia Cristina Fávaro Moreira
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 10/19872-0 - Sex and hormonal status influence in the study of beta blockers effect in TMJ pain and allodynia in rodents and humans
Grantee:Claudia Herrera Tambeli
Support Opportunities: Regular Research Grants