Oxidative Stress Status and Placental Implications in Diabetic Rats Undergoing Swimming Exercise After Embryonic Implantation

Author(s)

Volpato, Gustavo Tadeu ^{[1, 2]} ; Damasceno, Debora Cristina ^[1] ; Sinzato, Yuri Karen ^[1] ; Ribeiro, Viviane Maria ^[1] ; Cunha Rudge, Marilza Vieira ^[1] ; Paranhos Calderon, Iracema Mattos ^[1]

Affiliation

^[1] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Sao Paulo - Brazil

^[2] Univ Fed Mato Grosso, Univ Ctr Araguaia, Inst Biol & Hlth Sci, Lab Gen Physiol & Reprod Toxicol, Barra Do Garcas, Mato Grosso - Brazil

• Document type: Journal article
• Source: REPRODUCTIVE SCIENCES; v. 22, n. 5, p. 602-608, MAY 2015.
• Web of Science Citations: 13

Abstract

The potential benefits and risks of physical exercise on fetal development during pregnancy remain unclear. The aim was to analyze maternal oxidative stress status and the placental morphometry to relate to intrauterine growth restriction (IUGR) from diabetic female rats submitted to swimming program after embryonic implantation. Pregnant Wistar rats were distributed into 4 groups (11 animals/group): controlnondiabetic sedentary rats, control exercisednondiabetic exercised rats, diabeticdiabetic sedentary rats, and diabetic exerciseddiabetic exercised rats. A swimming program was used as an exercise model. At the end of pregnancy, the maternal oxidative stress status, placental morphology, and fetal weight were analyzed. The swimming program was not efficient to reduce the hyperglycemia-induced oxidative stress. This fact impaired placental development, resulting in altered blood flow and energy reserves, which contributed to a deficient exchange of nutrients and oxygen for the fetal development, leading to IUGR. (AU)

• FAPESP's process: 08/03881-0 - Exercise in pegnant diabetic rats: Maternal-palcental repercussions
• Grantee: Viviane Maria Ribeiro
• Support Opportunities: Scholarships in Brazil - Scientific Initiation